Coagulation factor and protease pathways in thrombosis and cardiovascular disease

The biochemical characterisation of the proteolytic pathways that constitute blood coagulation was one of the most relevant achievements in biomedical research during the second half of the 20th century. Understanding these pathways was of crucial importance for improving global health through appli...

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Detalles Bibliográficos
Autores: Cate, Hugo ten, Hackeng, Tilman M., García de Frutos, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/177360
Acceso en línea:http://hdl.handle.net/10261/177360
Access Level:acceso abierto
Palabra clave:Atherothrombosis
Coagulation factors
Coagulation inhibitors
Proteases
Protein C/S pathway
Thrombosis
TFPI
Vitamin K-dependent factors
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spelling Coagulation factor and protease pathways in thrombosis and cardiovascular diseaseCate, Hugo tenHackeng, Tilman M.García de Frutos, PabloAtherothrombosisCoagulation factorsCoagulation inhibitorsProteasesProtein C/S pathwayThrombosisTFPIVitamin K-dependent factorsThe biochemical characterisation of the proteolytic pathways that constitute blood coagulation was one of the most relevant achievements in biomedical research during the second half of the 20th century. Understanding these pathways was of crucial importance for improving global health through application in haemostasis and thrombosis pathologies. Immediately after the cloning of the genes corresponding to these proteins, mutations were discovered in them that were associated with imbalances in haemostasis. Later, the importance of coagulation pathways in other pathological processes was demonstrated, such as in atherosclerosis and inflammation, both essential processes involved in vascular disease. In the present review we evaluate the concepts that have allowed us to reach the integrated vision on coagulation that we have today. The thrombo-inflammation model encompassing these aspects includes a pivotal role for the proteases of the coagulation pathway as well as the regulatory proteins thereof. These concepts illustrate the importance of the coagulation cascade in cardiovascular pathology, not only in thrombotic processes, but also in atherosclerotic processes and in the response to ischaemia-reperfusion injury, making it a central mechanism in cardiovascular disease.Peer reviewedThiemeConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/177360reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1160/TH17-02-0079Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1773602026-05-22T06:33:51Z
dc.title.none.fl_str_mv Coagulation factor and protease pathways in thrombosis and cardiovascular disease
title Coagulation factor and protease pathways in thrombosis and cardiovascular disease
spellingShingle Coagulation factor and protease pathways in thrombosis and cardiovascular disease
Cate, Hugo ten
Atherothrombosis
Coagulation factors
Coagulation inhibitors
Proteases
Protein C/S pathway
Thrombosis
TFPI
Vitamin K-dependent factors
title_short Coagulation factor and protease pathways in thrombosis and cardiovascular disease
title_full Coagulation factor and protease pathways in thrombosis and cardiovascular disease
title_fullStr Coagulation factor and protease pathways in thrombosis and cardiovascular disease
title_full_unstemmed Coagulation factor and protease pathways in thrombosis and cardiovascular disease
title_sort Coagulation factor and protease pathways in thrombosis and cardiovascular disease
dc.creator.none.fl_str_mv Cate, Hugo ten
Hackeng, Tilman M.
García de Frutos, Pablo
author Cate, Hugo ten
author_facet Cate, Hugo ten
Hackeng, Tilman M.
García de Frutos, Pablo
author_role author
author2 Hackeng, Tilman M.
García de Frutos, Pablo
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Atherothrombosis
Coagulation factors
Coagulation inhibitors
Proteases
Protein C/S pathway
Thrombosis
TFPI
Vitamin K-dependent factors
topic Atherothrombosis
Coagulation factors
Coagulation inhibitors
Proteases
Protein C/S pathway
Thrombosis
TFPI
Vitamin K-dependent factors
description The biochemical characterisation of the proteolytic pathways that constitute blood coagulation was one of the most relevant achievements in biomedical research during the second half of the 20th century. Understanding these pathways was of crucial importance for improving global health through application in haemostasis and thrombosis pathologies. Immediately after the cloning of the genes corresponding to these proteins, mutations were discovered in them that were associated with imbalances in haemostasis. Later, the importance of coagulation pathways in other pathological processes was demonstrated, such as in atherosclerosis and inflammation, both essential processes involved in vascular disease. In the present review we evaluate the concepts that have allowed us to reach the integrated vision on coagulation that we have today. The thrombo-inflammation model encompassing these aspects includes a pivotal role for the proteases of the coagulation pathway as well as the regulatory proteins thereof. These concepts illustrate the importance of the coagulation cascade in cardiovascular pathology, not only in thrombotic processes, but also in atherosclerotic processes and in the response to ischaemia-reperfusion injury, making it a central mechanism in cardiovascular disease.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/177360
url http://hdl.handle.net/10261/177360
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1160/TH17-02-0079
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Thieme
publisher.none.fl_str_mv Thieme
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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