How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices

Purpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively. Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator a...

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Autores: Trujillo Guillén, Macarena, Prakash, Punit, Faridi, Pegah, Radosevic, Aleksandar, 1974-, Curto, Sergio, Burdío Pinilla, Fernando, Berjano, Enrique J.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/46593
Acesso em linha:http://hdl.handle.net/10230/46593
http://dx.doi.org/10.1080/02656736.2020.1823022
Access Level:acceso abierto
Palavra-chave:Microwave ablation
Moderate hyperthermic heating
Periablational zone
Radiofrequency ablation
Thermal ablation
Tumor ablation
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spelling How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devicesTrujillo Guillén, MacarenaPrakash, PunitFaridi, PegahRadosevic, Aleksandar, 1974-Curto, SergioBurdío Pinilla, FernandoBerjano, Enrique J.Microwave ablationModerate hyperthermic heatingPeriablational zoneRadiofrequency ablationThermal ablationTumor ablationPurpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively. Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (Ω). CZ was considered when Ω > 4.6 (>99% of damaged cells). Regions with 0.6<Ω < 2.1 were considered as the PZ (tissue that has undergone moderate sub-ablative hyperthermia). The ratio of PZ volume to CZ volume (PZ/CZ) was regarded as a measure of performance, since a low value implies achieving a large CZ while keeping the PZ small. Results: Ten-min RFA (51 W) created smaller periablational zones than 10-min MWA (11.3 cm3 vs. 17.2-22.9 cm3, for 60-100 W MWA, respectively). Prolonging duration from 5 to 10 min increased the PZ in MWA more than in RFA (2.7 cm3 for RFA vs. 8.3-11.9 cm3 for 60-100 W MWA, respectively). PZ/CZ for RFA were relatively high (65-69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10 min) and on the applied power (smaller values as power was raised, 102% for 60 W vs. 81% for 100 W, both for 10 min). The lowest PZ/CZ across all settings was 56%, obtained with 100 W-5 min MWA. Conclusions: Although RFA creates smaller periablational zones than MWA, 100 W-5 min MWA provides the lowest PZ/CZ.This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades under “Programa Estatal de I + D + i Orientada a los Retos de la Sociedad”, Grant N° “RTI2018-094357-B-C21”. Punit Prakash acknowledges support from NIH grant R01EB028848. This project has also received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845645.Taylor & Francis202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46593http://dx.doi.org/10.1080/02656736.2020.1823022reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Hyperthermia. 2020; 37(1):1131-8info:eu-repo/grantAgreement/EC/H2020/845645© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/465932026-06-12T07:21:37Z
dc.title.none.fl_str_mv How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
title How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
spellingShingle How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
Trujillo Guillén, Macarena
Microwave ablation
Moderate hyperthermic heating
Periablational zone
Radiofrequency ablation
Thermal ablation
Tumor ablation
title_short How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
title_full How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
title_fullStr How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
title_full_unstemmed How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
title_sort How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
dc.creator.none.fl_str_mv Trujillo Guillén, Macarena
Prakash, Punit
Faridi, Pegah
Radosevic, Aleksandar, 1974-
Curto, Sergio
Burdío Pinilla, Fernando
Berjano, Enrique J.
author Trujillo Guillén, Macarena
author_facet Trujillo Guillén, Macarena
Prakash, Punit
Faridi, Pegah
Radosevic, Aleksandar, 1974-
Curto, Sergio
Burdío Pinilla, Fernando
Berjano, Enrique J.
author_role author
author2 Prakash, Punit
Faridi, Pegah
Radosevic, Aleksandar, 1974-
Curto, Sergio
Burdío Pinilla, Fernando
Berjano, Enrique J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Microwave ablation
Moderate hyperthermic heating
Periablational zone
Radiofrequency ablation
Thermal ablation
Tumor ablation
topic Microwave ablation
Moderate hyperthermic heating
Periablational zone
Radiofrequency ablation
Thermal ablation
Tumor ablation
description Purpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively. Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (Ω). CZ was considered when Ω > 4.6 (>99% of damaged cells). Regions with 0.6<Ω < 2.1 were considered as the PZ (tissue that has undergone moderate sub-ablative hyperthermia). The ratio of PZ volume to CZ volume (PZ/CZ) was regarded as a measure of performance, since a low value implies achieving a large CZ while keeping the PZ small. Results: Ten-min RFA (51 W) created smaller periablational zones than 10-min MWA (11.3 cm3 vs. 17.2-22.9 cm3, for 60-100 W MWA, respectively). Prolonging duration from 5 to 10 min increased the PZ in MWA more than in RFA (2.7 cm3 for RFA vs. 8.3-11.9 cm3 for 60-100 W MWA, respectively). PZ/CZ for RFA were relatively high (65-69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10 min) and on the applied power (smaller values as power was raised, 102% for 60 W vs. 81% for 100 W, both for 10 min). The lowest PZ/CZ across all settings was 56%, obtained with 100 W-5 min MWA. Conclusions: Although RFA creates smaller periablational zones than MWA, 100 W-5 min MWA provides the lowest PZ/CZ.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/46593
http://dx.doi.org/10.1080/02656736.2020.1823022
url http://hdl.handle.net/10230/46593
http://dx.doi.org/10.1080/02656736.2020.1823022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Hyperthermia. 2020; 37(1):1131-8
info:eu-repo/grantAgreement/EC/H2020/845645
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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