Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome

Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hos...

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Autores: Real de Asua, Diego, Mayer, Miguel Ángel, 1960-, Ortega, María del Carmen, Borrel, Jose M., Bermejo, Teresa de Jesús, González Lamuño, Domingo, Manso, Coral, Moldenhauer, Fernando, Carmona Iragui, María, Hüls, Anke, Sherman, Stephanie L., Strydom, Andre, Torre Fornell, Rafael de la, Dierssen, Mara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48677
Acceso en línea:http://hdl.handle.net/10230/48677
http://dx.doi.org/10.3390/jcm10163748
Access Level:acceso abierto
Palabra clave:COVID-19
Down syndrome
SARS-CoV-2
Pneumonia
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spelling Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndromeReal de Asua, DiegoMayer, Miguel Ángel, 1960-Ortega, María del CarmenBorrel, Jose M.Bermejo, Teresa de JesúsGonzález Lamuño, DomingoManso, CoralMoldenhauer, FernandoCarmona Iragui, MaríaHüls, AnkeSherman, Stephanie L.Strydom, AndreTorre Fornell, Rafael de laDierssen, MaraCOVID-19Down syndromeSARS-CoV-2PneumoniaWhether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19.The lab of M.D. is supported by the Departament d’Universitats, Recerca i Societat de la Informació de la Generalitat de Catalunya (Grups consolidats 2017 SGR 926, 2017 SGR 138). We also acknowledge the support of the Agencia Estatal de Investigación (PID2019-110755RB-I00/AEI/10.13039/501100011033), the European Union’s Horizon 2020 research and innovation programme under grant agreement No 848077, Jerôme Lejeune Foundation (No 2002), NIH (Grant Number: 1R01EB 028159-01), Marató TV3 (#2016/20-30), JPND Heroes project. CRG acknowledges the support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme/Generalitat de Catalunya. The CIBER of Rare Diseases (CIBERER) and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN) are initiatives of the ISCIII. D.R.A. is partially supported by the Fondo de Investigaciones Sanitarias (FIS grant PI19/00634, European Fund for Regional Development—EFRD) and the Foundation Jérôme Lejeune (grant no. 1777-2018). The Research Programme on Biomedical Informatics (GRIB) is a member of the Spanish National Bioinformatics Institute (INB), funded by ISCIII and EDER (PT17/0009/0014). The DCEXS is a ‘Unidad de Excelencia María de Maeztu’, funded by the AEI (CEX2018-000782-M). The GRIB is also supported by the Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya (2017 SGR 00519). AH was supported by the HERCULES Center (NIEHS P30ES019776) and by the LuMind IDSC Foundation.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48677http://dx.doi.org/10.3390/jcm10163748reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJ Clin Med. 2021;10(16):3748info:eu-repo/grantAgreement/EC/H2020/848077© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/486772026-06-12T07:21:37Z
dc.title.none.fl_str_mv Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
title Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
spellingShingle Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
Real de Asua, Diego
COVID-19
Down syndrome
SARS-CoV-2
Pneumonia
title_short Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
title_full Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
title_fullStr Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
title_full_unstemmed Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
title_sort Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
dc.creator.none.fl_str_mv Real de Asua, Diego
Mayer, Miguel Ángel, 1960-
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
Torre Fornell, Rafael de la
Dierssen, Mara
author Real de Asua, Diego
author_facet Real de Asua, Diego
Mayer, Miguel Ángel, 1960-
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
Torre Fornell, Rafael de la
Dierssen, Mara
author_role author
author2 Mayer, Miguel Ángel, 1960-
Ortega, María del Carmen
Borrel, Jose M.
Bermejo, Teresa de Jesús
González Lamuño, Domingo
Manso, Coral
Moldenhauer, Fernando
Carmona Iragui, María
Hüls, Anke
Sherman, Stephanie L.
Strydom, Andre
Torre Fornell, Rafael de la
Dierssen, Mara
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Down syndrome
SARS-CoV-2
Pneumonia
topic COVID-19
Down syndrome
SARS-CoV-2
Pneumonia
description Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48677
http://dx.doi.org/10.3390/jcm10163748
url http://hdl.handle.net/10230/48677
http://dx.doi.org/10.3390/jcm10163748
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv J Clin Med. 2021;10(16):3748
info:eu-repo/grantAgreement/EC/H2020/848077
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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