Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial
Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in th...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/113206 |
| Acceso en línea: | https://hdl.handle.net/10171/113206 |
| Access Level: | acceso abierto |
| Palabra clave: | Randomized clinical trial Lifestyle Biomarker Atrial fibrillation |
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Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trialLi, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669cAlonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13eRomaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680aAlonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2dRazquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47Fiol, M. (Miquel)|||/items/5d318070-a49f-4a89-8633-7809d4934fa2Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Subramanya, V. (Vinita)|||/items/f031010d-67b8-41d1-9dee-2db2d937fbebSalas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6bToledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Randomized clinical trialLifestyleBiomarkerAtrial fibrillationBackground: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55–75 years) with metabolic syndrome and body mass index between 27–40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants’ mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were −0.01 (PICP), 0.20 (hsTnT), −0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (−14%, 95% confidence interval (CI) −26%, 0%) or smaller increases in 3-NT (−16%, 95% CI −25%, −5%) and NT-proBNP (−12%, 95% CI −23%, 1%). The intervention had minimal impact on hsTnT (−3%, 95% CI −7%, 2%) or PICP concentrations (−2%, 95% CI −9%, 6%). The effect of the intervention on hsCRP was primarily mediated by weight loss (89% at year 5). Conclusions: Over five years, a dietary and lifestyle intervention for weight-loss favorably affected concentrations of hsCRP, 3-NT, and NT-proBNP, pointing to specific mechanisms in pathways linking lifestyles and AF.MDPIDadun. Depósito Académico Digital Universidad de Navarra20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/113206reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1132062026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| title |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| spellingShingle |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial Li, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669c Randomized clinical trial Lifestyle Biomarker Atrial fibrillation |
| title_short |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| title_full |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| title_fullStr |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| title_full_unstemmed |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| title_sort |
Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial |
| dc.creator.none.fl_str_mv |
Li, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669c Alonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fiol, M. (Miquel)|||/items/5d318070-a49f-4a89-8633-7809d4934fa2 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Subramanya, V. (Vinita)|||/items/f031010d-67b8-41d1-9dee-2db2d937fbeb Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
| author |
Li, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669c |
| author_facet |
Li, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669c Alonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fiol, M. (Miquel)|||/items/5d318070-a49f-4a89-8633-7809d4934fa2 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Subramanya, V. (Vinita)|||/items/f031010d-67b8-41d1-9dee-2db2d937fbeb Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
| author_role |
author |
| author2 |
Alonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fiol, M. (Miquel)|||/items/5d318070-a49f-4a89-8633-7809d4934fa2 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Subramanya, V. (Vinita)|||/items/f031010d-67b8-41d1-9dee-2db2d937fbeb Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
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author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Randomized clinical trial Lifestyle Biomarker Atrial fibrillation |
| topic |
Randomized clinical trial Lifestyle Biomarker Atrial fibrillation |
| description |
Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55–75 years) with metabolic syndrome and body mass index between 27–40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants’ mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were −0.01 (PICP), 0.20 (hsTnT), −0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (−14%, 95% confidence interval (CI) −26%, 0%) or smaller increases in 3-NT (−16%, 95% CI −25%, −5%) and NT-proBNP (−12%, 95% CI −23%, 1%). The intervention had minimal impact on hsTnT (−3%, 95% CI −7%, 2%) or PICP concentrations (−2%, 95% CI −9%, 6%). The effect of the intervention on hsCRP was primarily mediated by weight loss (89% at year 5). Conclusions: Over five years, a dietary and lifestyle intervention for weight-loss favorably affected concentrations of hsCRP, 3-NT, and NT-proBNP, pointing to specific mechanisms in pathways linking lifestyles and AF. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01 2024 2024-01-01 |
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journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/113206 |
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https://hdl.handle.net/10171/113206 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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