Effect of an intensive lifestyle intervention on circulating biomarkers of atrial fibrillation-related pathways among adults with metabolic syndrome: results from a randomized trial

Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in th...

Descripción completa

Detalles Bibliográficos
Autores: Li, L. (Linzi)|||/items/55b05641-29db-4f66-8f7e-85477a85669c, Alonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13e, Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a, Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d, Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06, Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47, Fiol, M. (Miquel)|||/items/5d318070-a49f-4a89-8633-7809d4934fa2, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Subramanya, V. (Vinita)|||/items/f031010d-67b8-41d1-9dee-2db2d937fbeb, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/113206
Acceso en línea:https://hdl.handle.net/10171/113206
Access Level:acceso abierto
Palabra clave:Randomized clinical trial
Lifestyle
Biomarker
Atrial fibrillation
Descripción
Sumario:Background: Lifestyles influence atrial fibrillation (AF) risk. Determining the effect of lifestyle interventions on blood concentrations of biomarkers of AF-related pathways could help understand AF pathophysiology and contribute to AF prevention. Methods: We studied 532 participants enrolled in the PREDIMED-Plus trial, a Spanish randomized trial conducted in adults (55–75 years) with metabolic syndrome and body mass index between 27–40 kg/m2. Eligible participants were randomized 1:1 to an intensive lifestyle intervention, emphasizing physical activity, weight loss, and adherence to an energy-reduced Mediterranean diet or to a control group. Serum biomarkers [carboxy-terminal propeptide of procollagen type I (PICP), high-sensitivity troponin T (hsTnT), high-sensitivity C reactive protein (hsCRP), 3-nitrotyrosine (3-NT), and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP)] were measured at baseline, 3 and 5 years after randomization. Mixed models were used to evaluate the effect of intervention on changes in biomarkers through year 5. Mediation analysis was performed to examine the proportion mediated by each component of the intervention. Results: At baseline, participants’ mean age was 65, 40% were female, and 50% were assigned to the intervention. After five years, mean changes in log-transformed biomarkers were −0.01 (PICP), 0.20 (hsTnT), −0.17 (hsCRP), 0.12 (3-NT), and 0.27 (NT-proBNP). Compared to the control group, participants in the intervention group experienced greater decreases in hsCRP (−14%, 95% confidence interval (CI) −26%, 0%) or smaller increases in 3-NT (−16%, 95% CI −25%, −5%) and NT-proBNP (−12%, 95% CI −23%, 1%). The intervention had minimal impact on hsTnT (−3%, 95% CI −7%, 2%) or PICP concentrations (−2%, 95% CI −9%, 6%). The effect of the intervention on hsCRP was primarily mediated by weight loss (89% at year 5). Conclusions: Over five years, a dietary and lifestyle intervention for weight-loss favorably affected concentrations of hsCRP, 3-NT, and NT-proBNP, pointing to specific mechanisms in pathways linking lifestyles and AF.

Similares en LA Referencia