Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on mem...
| Autores: | , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/70857 |
| Acesso em linha: | http://hdl.handle.net/10230/70857 http://dx.doi.org/10.1038/s41467-024-51416-4 |
| Access Level: | acceso abierto |
| Palavra-chave: | Astrocyte Olfactory bulb Stress and resilience |
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Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male miceGómez-Sotres, PaulaSkupio, UrszulaDalla Tor, TommasoJulio-Kalajzić, FranciscaCannich, AstridGisquet, DorianeBonilla-Del Río, ItziarDrago, FilippoPuente, NagoreGrandes, PedroBellocchio, LuigiBusquets Garcia, Arnau, 1985-Bains, Jaideep S.Marsicano, GiovanniAstrocyteOlfactory bulbStress and resilienceEmotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.This study was funded by Inserm (to G.M); the European Research Council (Micabra, ERC-2017-AdG-786467, to G.M); Fondation pour la Recherche Medicale (DRM20101220445, to G.M; SPF201809006908 to U.S); the Human Frontiers Science Program (to G.M); Region Aquitaine (CanBrain, AAP2022A-2021-16763610 and −17219710 to G.M); French State/Agence Nationale de la Recherche (ERA-Net Neuron CanShank, ANR-21-NEU2-0001-04, to G.M), (CaMeLS, ANR-23-CE16-0022-01, to G.M), (Hippobese, ANR-23-CE14-0004-03, to G.M); the French government in the framework of the University of Bordeaux IdEx “Investments for the Future” program / GPR BRAIN_2030 (to P.G-S and G.M) and Bordeaux Collaboration Scheme (to P.G-S); La Caixa Research Health grant HR23-00793 (to G.M. and A. B-G); the Canadian Institutes for Health and Research (FDN-148440 to J.S.B); The Basque Government (IT1620-22 to P.G); Atención Primaria, Cronicidad y Promoción de la Salud, Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III (RD21/0009/0006 to P.G)Nature Research202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70857http://dx.doi.org/10.1038/s41467-024-51416-4reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNat Commun. 2024 Aug 18;15(1):7103info:eu-repo/grantAgreement/EC/H2020/786467© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/708572026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| title |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| spellingShingle |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice Gómez-Sotres, Paula Astrocyte Olfactory bulb Stress and resilience |
| title_short |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| title_full |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| title_fullStr |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| title_full_unstemmed |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| title_sort |
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice |
| dc.creator.none.fl_str_mv |
Gómez-Sotres, Paula Skupio, Urszula Dalla Tor, Tommaso Julio-Kalajzić, Francisca Cannich, Astrid Gisquet, Doriane Bonilla-Del Río, Itziar Drago, Filippo Puente, Nagore Grandes, Pedro Bellocchio, Luigi Busquets Garcia, Arnau, 1985- Bains, Jaideep S. Marsicano, Giovanni |
| author |
Gómez-Sotres, Paula |
| author_facet |
Gómez-Sotres, Paula Skupio, Urszula Dalla Tor, Tommaso Julio-Kalajzić, Francisca Cannich, Astrid Gisquet, Doriane Bonilla-Del Río, Itziar Drago, Filippo Puente, Nagore Grandes, Pedro Bellocchio, Luigi Busquets Garcia, Arnau, 1985- Bains, Jaideep S. Marsicano, Giovanni |
| author_role |
author |
| author2 |
Skupio, Urszula Dalla Tor, Tommaso Julio-Kalajzić, Francisca Cannich, Astrid Gisquet, Doriane Bonilla-Del Río, Itziar Drago, Filippo Puente, Nagore Grandes, Pedro Bellocchio, Luigi Busquets Garcia, Arnau, 1985- Bains, Jaideep S. Marsicano, Giovanni |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Astrocyte Olfactory bulb Stress and resilience |
| topic |
Astrocyte Olfactory bulb Stress and resilience |
| description |
Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/70857 http://dx.doi.org/10.1038/s41467-024-51416-4 |
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http://hdl.handle.net/10230/70857 http://dx.doi.org/10.1038/s41467-024-51416-4 |
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Inglés |
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Inglés |
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Nat Commun. 2024 Aug 18;15(1):7103 info:eu-repo/grantAgreement/EC/H2020/786467 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Nature Research |
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Nature Research |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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