Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on mem...

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Bibliographic Details
Authors: Gómez Sotres, Paula, Skupio, Urszula, Dalla Tor, Tommaso, Julio Kalajzić, Francisca, Cannich, Astrid, Gisquet, Doriane, Bonilla del Río, Itziar, Drago, Filippo, Puente Bustinza, Nagore, Grandes Moreno, Pedro Rolando, Bellocchio, Luigi, Busquets García, Arnau, Bains, Jaideep S., Marsicano, Giovanni
Format: article
Publication Date:2024
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/69355
Online Access:http://hdl.handle.net/10810/69355
Access Level:Open access
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Summary:Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.

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