Tamoxifen/montmorillonite system – Effect of the experimental conditions

A new nano system based on drug/clay minerals is sought as an alternative to the current options due to the limitations of the conventional treatment. In this study, experimental conditions, such as pH, reaction duration and initial drug concentration, were evaluated to obtain systems based on the a...

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Autores: Silva, D. T. C., Arruda, I. E. S., França, L. M., França, D. B., Fonseca, M. G., Soares, M. F. L. R., Viseras, C., Soares-Sobrinho, J. L.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/206385
Acceso en línea:http://hdl.handle.net/10261/206385
Access Level:acceso abierto
Palabra clave:Clays
Montmorillonite
Tamoxifen
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spelling Tamoxifen/montmorillonite system – Effect of the experimental conditionsSilva, D. T. C.Arruda, I. E. S.França, L. M.França, D. B.Fonseca, M. G.Soares, M. F. L. R.Viseras, C.Soares-Sobrinho, J. L.ClaysMontmorilloniteTamoxifenA new nano system based on drug/clay minerals is sought as an alternative to the current options due to the limitations of the conventional treatment. In this study, experimental conditions, such as pH, reaction duration and initial drug concentration, were evaluated to obtain systems based on the anticancer drug tamoxifen (TMX) and montmorillonite. Equilibrium and kinetic studies were developed for montmorillonite (VHS)/TMX at pH values in the range of 1.5 to 7.0 for reaction times of 1 to 720 min and drug concentrations of 533 to 2300 mg·L. The solids were characterized by using X-ray diffraction and middle infrared spectroscopy (MID). The interaction of TMX with montmorillonite was pH-dependent with a higher adsorption at pH 5.5 (402.63 mg·g). For all pH values, intercalation of the drug was the preponderant mechanism of interaction. The system was described by a pseudo-second-order model. In the equilibrium study, the data adsorption was fitted to Langmuir model. Therefore, the reaction between TMX and montmorillonite was effective, and the best experimental conditions to obtain the studied hybrids were at pH 5.5 for 720 min and 2300 mg·L drug concentration.This study was supported by the projects IBPG-1457-4.03/15 financed by FACEPE.Elsevier BVConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/206385reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.clay.2019.105142Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2063852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Tamoxifen/montmorillonite system – Effect of the experimental conditions
title Tamoxifen/montmorillonite system – Effect of the experimental conditions
spellingShingle Tamoxifen/montmorillonite system – Effect of the experimental conditions
Silva, D. T. C.
Clays
Montmorillonite
Tamoxifen
title_short Tamoxifen/montmorillonite system – Effect of the experimental conditions
title_full Tamoxifen/montmorillonite system – Effect of the experimental conditions
title_fullStr Tamoxifen/montmorillonite system – Effect of the experimental conditions
title_full_unstemmed Tamoxifen/montmorillonite system – Effect of the experimental conditions
title_sort Tamoxifen/montmorillonite system – Effect of the experimental conditions
dc.creator.none.fl_str_mv Silva, D. T. C.
Arruda, I. E. S.
França, L. M.
França, D. B.
Fonseca, M. G.
Soares, M. F. L. R.
Viseras, C.
Soares-Sobrinho, J. L.
author Silva, D. T. C.
author_facet Silva, D. T. C.
Arruda, I. E. S.
França, L. M.
França, D. B.
Fonseca, M. G.
Soares, M. F. L. R.
Viseras, C.
Soares-Sobrinho, J. L.
author_role author
author2 Arruda, I. E. S.
França, L. M.
França, D. B.
Fonseca, M. G.
Soares, M. F. L. R.
Viseras, C.
Soares-Sobrinho, J. L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Clays
Montmorillonite
Tamoxifen
topic Clays
Montmorillonite
Tamoxifen
description A new nano system based on drug/clay minerals is sought as an alternative to the current options due to the limitations of the conventional treatment. In this study, experimental conditions, such as pH, reaction duration and initial drug concentration, were evaluated to obtain systems based on the anticancer drug tamoxifen (TMX) and montmorillonite. Equilibrium and kinetic studies were developed for montmorillonite (VHS)/TMX at pH values in the range of 1.5 to 7.0 for reaction times of 1 to 720 min and drug concentrations of 533 to 2300 mg·L. The solids were characterized by using X-ray diffraction and middle infrared spectroscopy (MID). The interaction of TMX with montmorillonite was pH-dependent with a higher adsorption at pH 5.5 (402.63 mg·g). For all pH values, intercalation of the drug was the preponderant mechanism of interaction. The system was described by a pseudo-second-order model. In the equilibrium study, the data adsorption was fitted to Langmuir model. Therefore, the reaction between TMX and montmorillonite was effective, and the best experimental conditions to obtain the studied hybrids were at pH 5.5 for 720 min and 2300 mg·L drug concentration.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/206385
url http://hdl.handle.net/10261/206385
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.clay.2019.105142
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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