Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Helmy, R; Denhaerynck, K; Berben, L; Dobbels, F; Russell, CL; Roza, BD; De Geest, S; Crespo-Leiro, MG; Guppies, S; De Simone, P; Groenewoud, A; Kugler, C; Ohler, L; Van Cleemput, J; Poncelet, AJ; Sebbag, L; Michel, M; Bernard, A; Doesch, A; Livi, U; Potena, L; Brossa-Loidi, V; Segovia-Cubero, J; Almenar-Bonet, L; Saint-Gerons, CS; Mohacsi, P; Horvath, E; Riotto, C; Parry, G; Firouzi, A; Kozuszko, S; Haddad, H; Kaan, A; Fisher, G; Miller, T; Flattery, M; Ludrosky, K; Albert, N; Coleman, B; Trammell, J; Epstein, F; St Clair, K; Kao, A; Molina, M; Canales, KR; de Almeida, SS; Ayoub, AC; Barone, F; Harkess, M; Maddicks-Law, J; BRIGHT Study Team

Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale...

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Autores:	Helmy, R, Denhaerynck, K, Berben, L, Dobbels, F, Russell, CL, Roza, BD, De Geest, S, Crespo-Leiro, MG, Guppies, S, De Simone, P, Groenewoud, A, Kugler, C, Ohler, L, Van Cleemput, J, Poncelet, AJ, Sebbag, L, Michel, M, Bernard, A, Doesch, A, Livi, U, Potena, L, Brossa-Loidi, V, Segovia-Cubero, J, Almenar-Bonet, L, Saint-Gerons, CS, Mohacsi, P, Horvath, E, Riotto, C, Parry, G, Firouzi, A, Kozuszko, S, Haddad, H, Kaan, A, Fisher, G, Miller, T, Flattery, M, Ludrosky, K, Albert, N, Coleman, B, Trammell, J, Epstein, F, St Clair, K, Kao, A, Molina, M, Canales, KR, de Almeida, SS, Ayoub, AC, Barone, F, Harkess, M, Maddicks-Law, J, BRIGHT Study Team
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2019
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p3089
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3089 https://lirias.kuleuven.be/2350157&lang=en
Access Level:	acceso abierto
Palabra clave:	co-medications cross-sectional heart transplantation immunosuppressants international medication adherence

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spelling	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT StudyHelmy, RDenhaerynck, KBerben, LDobbels, FRussell, CLRoza, BDDe Geest, SCrespo-Leiro, MGGuppies, SDe Simone, PGroenewoud, AKugler, COhler, LVan Cleemput, JPoncelet, AJSebbag, LMichel, MBernard, ADoesch, ALivi, UPotena, LBrossa-Loidi, VSegovia-Cubero, JAlmenar-Bonet, LSaint-Gerons, CSMohacsi, PHorvath, ERiotto, CParry, GFirouzi, AKozuszko, SHaddad, HKaan, AFisher, GMiller, TFlattery, MLudrosky, KAlbert, NColeman, BTrammell, JEpstein, FSt Clair, KKao, AMolina, MCanales, KRde Almeida, SSAyoub, ACBarone, FHarkess, MMaddicks-Law, JBRIGHT Study Teamco-medicationscross-sectionalheart transplantationimmunosuppressantsinternationalmedication adherencePurpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.ELSEVIER2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3089https://lirias.kuleuven.be/2350157&lang=enCLINICAL THERAPEUTICSISSN: 01492918ISSNe: 1879114Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p30892026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
title	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
spellingShingle	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study Helmy, R co-medications cross-sectional heart transplantation immunosuppressants international medication adherence
title_short	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
title_full	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
title_fullStr	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
title_full_unstemmed	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
title_sort	Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study
dc.creator.none.fl_str_mv	Helmy, R Denhaerynck, K Berben, L Dobbels, F Russell, CL Roza, BD De Geest, S Crespo-Leiro, MG Guppies, S De Simone, P Groenewoud, A Kugler, C Ohler, L Van Cleemput, J Poncelet, AJ Sebbag, L Michel, M Bernard, A Doesch, A Livi, U Potena, L Brossa-Loidi, V Segovia-Cubero, J Almenar-Bonet, L Saint-Gerons, CS Mohacsi, P Horvath, E Riotto, C Parry, G Firouzi, A Kozuszko, S Haddad, H Kaan, A Fisher, G Miller, T Flattery, M Ludrosky, K Albert, N Coleman, B Trammell, J Epstein, F St Clair, K Kao, A Molina, M Canales, KR de Almeida, SS Ayoub, AC Barone, F Harkess, M Maddicks-Law, J BRIGHT Study Team
author	Helmy, R
author_facet	Helmy, R Denhaerynck, K Berben, L Dobbels, F Russell, CL Roza, BD De Geest, S Crespo-Leiro, MG Guppies, S De Simone, P Groenewoud, A Kugler, C Ohler, L Van Cleemput, J Poncelet, AJ Sebbag, L Michel, M Bernard, A Doesch, A Livi, U Potena, L Brossa-Loidi, V Segovia-Cubero, J Almenar-Bonet, L Saint-Gerons, CS Mohacsi, P Horvath, E Riotto, C Parry, G Firouzi, A Kozuszko, S Haddad, H Kaan, A Fisher, G Miller, T Flattery, M Ludrosky, K Albert, N Coleman, B Trammell, J Epstein, F St Clair, K Kao, A Molina, M Canales, KR de Almeida, SS Ayoub, AC Barone, F Harkess, M Maddicks-Law, J BRIGHT Study Team
author_role	author
author2	Denhaerynck, K Berben, L Dobbels, F Russell, CL Roza, BD De Geest, S Crespo-Leiro, MG Guppies, S De Simone, P Groenewoud, A Kugler, C Ohler, L Van Cleemput, J Poncelet, AJ Sebbag, L Michel, M Bernard, A Doesch, A Livi, U Potena, L Brossa-Loidi, V Segovia-Cubero, J Almenar-Bonet, L Saint-Gerons, CS Mohacsi, P Horvath, E Riotto, C Parry, G Firouzi, A Kozuszko, S Haddad, H Kaan, A Fisher, G Miller, T Flattery, M Ludrosky, K Albert, N Coleman, B Trammell, J Epstein, F St Clair, K Kao, A Molina, M Canales, KR de Almeida, SS Ayoub, AC Barone, F Harkess, M Maddicks-Law, J BRIGHT Study Team
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	co-medications cross-sectional heart transplantation immunosuppressants international medication adherence
topic	co-medications cross-sectional heart transplantation immunosuppressants international medication adherence
description	Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.
publishDate	2019
dc.date.none.fl_str_mv	2019
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3089 https://lirias.kuleuven.be/2350157&lang=en
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3089 https://lirias.kuleuven.be/2350157&lang=en
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER
publisher.none.fl_str_mv	ELSEVIER
dc.source.none.fl_str_mv	CLINICAL THERAPEUTICS ISSN: 01492918 ISSNe: 1879114X reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

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