Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study

Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale...

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Detalles Bibliográficos
Autores: Helmy, R, Denhaerynck, K, Berben, L, Dobbels, F, Russell, CL, Roza, BD, De Geest, S, Crespo-Leiro, MG, Guppies, S, De Simone, P, Groenewoud, A, Kugler, C, Ohler, L, Van Cleemput, J, Poncelet, AJ, Sebbag, L, Michel, M, Bernard, A, Doesch, A, Livi, U, Potena, L, Brossa-Loidi, V, Segovia-Cubero, J, Almenar-Bonet, L, Saint-Gerons, CS, Mohacsi, P, Horvath, E, Riotto, C, Parry, G, Firouzi, A, Kozuszko, S, Haddad, H, Kaan, A, Fisher, G, Miller, T, Flattery, M, Ludrosky, K, Albert, N, Coleman, B, Trammell, J, Epstein, F, St Clair, K, Kao, A, Molina, M, Canales, KR, de Almeida, SS, Ayoub, AC, Barone, F, Harkess, M, Maddicks-Law, J, BRIGHT Study Team
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p3089
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3089
https://lirias.kuleuven.be/2350157&lang=en
Access Level:acceso abierto
Palabra clave:co-medications
cross-sectional
heart transplantation
immunosuppressants
international
medication adherence
Descripción
Sumario:Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

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