Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications

Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy an...

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Detalhes bibliográficos
Autores: Caló, Enrica, de Barros, Joao M. S., Fernández-Gutiérrez, Mar, San Román, Julio, Ballamy, Lucy, Khutoryanskiy, Vitaliy V.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/153791
Acesso em linha:http://hdl.handle.net/10261/153791
Access Level:acceso abierto
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spelling Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applicationsCaló, Enricade Barros, Joao M. S.Fernández-Gutiérrez, MarSan Román, JulioBallamy, LucyKhutoryanskiy, Vitaliy V.Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).The authors acknowledge the University of Reading and ConvaTec Ltd for funding this research project. Chemical Analysis Facility (University of Reading) is acknowledged for access to FTIR, NMR and SEM. Dr Radoslaw M. Kowalczyk is acknowledged for recording solid state NMR spectra and Miss Amanpreet Kaur for her help with SEM. Brett Symonds is thanked for analysis of the molecular weight of PVA samples using GPC and help during the preparation of this manuscript.Peer ReviewedRoyal Society of Chemistry (UK)University of ReadingConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720162017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/153791reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1039/c6ra08234cSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1537912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
title Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
spellingShingle Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
Caló, Enrica
title_short Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
title_full Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
title_fullStr Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
title_full_unstemmed Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
title_sort Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications
dc.creator.none.fl_str_mv Caló, Enrica
de Barros, Joao M. S.
Fernández-Gutiérrez, Mar
San Román, Julio
Ballamy, Lucy
Khutoryanskiy, Vitaliy V.
author Caló, Enrica
author_facet Caló, Enrica
de Barros, Joao M. S.
Fernández-Gutiérrez, Mar
San Román, Julio
Ballamy, Lucy
Khutoryanskiy, Vitaliy V.
author_role author
author2 de Barros, Joao M. S.
Fernández-Gutiérrez, Mar
San Román, Julio
Ballamy, Lucy
Khutoryanskiy, Vitaliy V.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv University of Reading
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/153791
url http://hdl.handle.net/10261/153791
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1039/c6ra08234c
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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