Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-: Alt -maleic anhydride) mixtures for wound care applications

Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy an...

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Detalles Bibliográficos
Autores: Caló, Enrica, de Barros, Joao M. S., Fernández-Gutiérrez, Mar, San Román, Julio, Ballamy, Lucy, Khutoryanskiy, Vitaliy V.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/153791
Acceso en línea:http://hdl.handle.net/10261/153791
Access Level:acceso abierto
Descripción
Sumario:Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).