Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging

This article belongs to the Special Issue Metallodrugs for Targeted Cancer Therapy.

Bibliographic Details
Authors: Redrado, Marta, Benedi, Andrea, Marzo, Isabel, Gimeno, M. Concepción, Fernández-Moreira, Vanesa
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261156
Online Access:http://hdl.handle.net/10261/261156
Access Level:Open access
Keyword:Photodynamic therapy
Dual emiter
Iridium
Optical properties
Fluorescence microscopy
Cytotoxicity
Mitochondria
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spelling Dual emissive Ir(III) complexes for photodynamic therapy and bioimagingRedrado, MartaBenedi, AndreaMarzo, IsabelGimeno, M. ConcepciónFernández-Moreira, VanesaPhotodynamic therapyDual emiterIridiumOptical propertiesFluorescence microscopyCytotoxicityMitochondriaThis article belongs to the Special Issue Metallodrugs for Targeted Cancer Therapy.Photodynamic therapy (PDT) is a cancer treatment still bearing enormous prospects of improvement. Within the toolbox of PDT, developing photosensitizers (PSs) that can specifically reach tumor cells and promote the generation of high concentration of reactive oxygen species (ROS) is a constant research goal. Mitochondria is known as a highly appealing target for PSs, thus being able to assess the biodistribution of the PSs prior to its light activation would be crucial for therapeutic maximization. Bifunctional Ir(III) complexes of the type [Ir(C^N)2(N^N-R)]+, where N^C is either phenylpyridine (ppy) or benzoquinoline (bzq), N^N is 2,2′-dipyridylamine (dpa) and R either anthracene (1 and 3) or acridine (2 and 4), have been developed as novel trackable PSs agents. Activation of the tracking or therapeutic function could be achieved specifically by irradiating the complex with a different light wavelength (405 nm vs. 470 nm respectively). Only complex 4 ([Ir(bzq)2(dpa-acr)]+) clearly showed dual emissive pattern, acridine based emission between 407–450 nm vs. Ir(III) based emission between 521 and 547 nm. The sensitivity of A549 lung cancer cells to 4 evidenced the importance of involving the metal center within the activation process of the PS, reaching values of photosensitivity over 110 times higher than in dark conditions. Moreover, complex 4 promoted apoptotic cell death and possibly the paraptotic pathway, as well as higher ROS generation under irradiation than in dark conditions. Complexes 2–4 accumulated in the mitochondria but species 2 and 4 also localizes in other subcellular organelles.This research was funded by the Agencia Estatal de Investigación (projects PID2019-104379RB-C21, RTI2018-097836-J-I00, RYC2018-025872-I and RED2018-102471-T), and Gobierno de Aragón-Fondo Social Europeo (E07_20R).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Gobierno de AragónEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261156reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104379RB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097836-J-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2018-025872-Iinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RED2018-102387-Thttps://doi.org/10.3390/pharmaceutics13091382Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2611562026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
title Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
spellingShingle Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
Redrado, Marta
Photodynamic therapy
Dual emiter
Iridium
Optical properties
Fluorescence microscopy
Cytotoxicity
Mitochondria
title_short Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
title_full Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
title_fullStr Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
title_full_unstemmed Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
title_sort Dual emissive Ir(III) complexes for photodynamic therapy and bioimaging
dc.creator.none.fl_str_mv Redrado, Marta
Benedi, Andrea
Marzo, Isabel
Gimeno, M. Concepción
Fernández-Moreira, Vanesa
author Redrado, Marta
author_facet Redrado, Marta
Benedi, Andrea
Marzo, Isabel
Gimeno, M. Concepción
Fernández-Moreira, Vanesa
author_role author
author2 Benedi, Andrea
Marzo, Isabel
Gimeno, M. Concepción
Fernández-Moreira, Vanesa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Gobierno de Aragón
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Photodynamic therapy
Dual emiter
Iridium
Optical properties
Fluorescence microscopy
Cytotoxicity
Mitochondria
topic Photodynamic therapy
Dual emiter
Iridium
Optical properties
Fluorescence microscopy
Cytotoxicity
Mitochondria
description This article belongs to the Special Issue Metallodrugs for Targeted Cancer Therapy.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261156
url http://hdl.handle.net/10261/261156
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104379RB-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097836-J-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2018-025872-I
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RED2018-102387-T
https://doi.org/10.3390/pharmaceutics13091382
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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