Phosphorogenic Dipyrrinato-Iridium(III) Complexes as Photosensitizers for Photodynamic Therapy.
We have designed and synthesized a family of Ir(III) metal complexes coordinated with two ciclometallated bis-phenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir(dipy)-1), an -chloroacetyl ester (Ir(dipy)-2) or a chain containing an ammonium catio...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/70366 |
| Acceso en línea: | http://hdl.handle.net/10810/70366 |
| Access Level: | acceso abierto |
| Palabra clave: | Dipyrromethenes Iridium(III) complexes photosensitizers singlet oxygen photodynamic therapy |
| Sumario: | We have designed and synthesized a family of Ir(III) metal complexes coordinated with two ciclometallated bis-phenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir(dipy)-1), an -chloroacetyl ester (Ir(dipy)-2) or a chain containing an ammonium cation (Ir(dipy)-3). The Ir(III) complexes feature a high triplet state population enabling red phosphorescence and efficient singlet oxygen generation. Ir(dipy)-2 and Ir(dipy)-3 are demonstrated to stain cells in both one-photon and two-photon confocal imaging. Moreover, Ir(dipy)-2 and Ir(dipy)-3 produce ROS in cells upon irradiation, inducing cell death by apoptosis. Colocalization studies in SK-Mel-103 cells show that Ir(dipy)-3 partially accumulated in mitochondria and induces upon irradiation a disruption in their morphology. Overall our studies demonstrate that the prepared Ir(III) act as photosensitizers able to kill cells under irradiation, being suitable candidates for photodynamic therapy applications. |
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