Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.

Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behaviou...

Descripción completa

Detalles Bibliográficos
Autores: Saravia, Rocío, Ten Blanco, Marc, Julià Hernández, Marina, Gagliano, Humberto, Andero, Raül, Armario, Antonio, Maldonado, Rafael, Berrendero, Fernando
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Francisco de Vitoria
Repositorio:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Idioma:inglés
OAI Identifier:oai:ddfv.ufv.es:10641/1540
Acceso en línea:http://hdl.handle.net/10641/1540
Access Level:acceso abierto
id ES_db7a3a9e14b9bcd087b7f8d2a1e40ecd
oai_identifier_str oai:ddfv.ufv.es:10641/1540
network_acronym_str ES
network_name_str España
repository_id_str
spelling Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.Saravia, RocíoTen Blanco, MarcJulià Hernández, MarinaGagliano, HumbertoAndero, RaülArmario, AntonioMaldonado, RafaelBerrendero, FernandoΔ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood. Here we investigate the effects of THC treatment as well as the consequences of concomitant THC and stress exposure during adolescence in the extinction of fear memory in adult mice. Adolescent mice treated with THC and exposed to stress exhibit impaired cued fear extinction in adulthood. However, no effect was observed in animals exposed to these two factors separately. Notably, resistance to fear extinction was associated with decreased neuronal activity in the basolateral amygdala (BLA) and the infralimbic prefrontal cortex, suggesting a long-term dysregulation of the fear circuit. These changes in neuronal activation were paralleled with structural plasticity alterations. Indeed, an increase of immature dendritic spines in pyramidal neurons of the BLA was revealed in mice simultaneously exposed to THC and stress. Corticosterone levels were also enhanced after the cued fear conditioning session in the same experimental group. These results show that an interaction between cannabis exposure and stress during adolescence may lead to long-term anxiety disorders characterized by the presence of pathological fear.20182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10641/1540reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad Francisco de VitoriaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/15402026-06-11T12:44:57Z
dc.title.none.fl_str_mv Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
title Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
spellingShingle Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
Saravia, Rocío
title_short Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
title_full Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
title_fullStr Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
title_full_unstemmed Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
title_sort Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.
dc.creator.none.fl_str_mv Saravia, Rocío
Ten Blanco, Marc
Julià Hernández, Marina
Gagliano, Humberto
Andero, Raül
Armario, Antonio
Maldonado, Rafael
Berrendero, Fernando
author Saravia, Rocío
author_facet Saravia, Rocío
Ten Blanco, Marc
Julià Hernández, Marina
Gagliano, Humberto
Andero, Raül
Armario, Antonio
Maldonado, Rafael
Berrendero, Fernando
author_role author
author2 Ten Blanco, Marc
Julià Hernández, Marina
Gagliano, Humberto
Andero, Raül
Armario, Antonio
Maldonado, Rafael
Berrendero, Fernando
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
description Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood. Here we investigate the effects of THC treatment as well as the consequences of concomitant THC and stress exposure during adolescence in the extinction of fear memory in adult mice. Adolescent mice treated with THC and exposed to stress exhibit impaired cued fear extinction in adulthood. However, no effect was observed in animals exposed to these two factors separately. Notably, resistance to fear extinction was associated with decreased neuronal activity in the basolateral amygdala (BLA) and the infralimbic prefrontal cortex, suggesting a long-term dysregulation of the fear circuit. These changes in neuronal activation were paralleled with structural plasticity alterations. Indeed, an increase of immature dendritic spines in pyramidal neurons of the BLA was revealed in mice simultaneously exposed to THC and stress. Corticosterone levels were also enhanced after the cued fear conditioning session in the same experimental group. These results show that an interaction between cannabis exposure and stress during adolescence may lead to long-term anxiety disorders characterized by the presence of pathological fear.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10641/1540
url http://hdl.handle.net/10641/1540
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname:Universidad Francisco de Vitoria
instname_str Universidad Francisco de Vitoria
reponame_str DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
collection DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421679117074432
score 15,300719

Similares en LA Referencia