Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs

A hydrogel/nanoparticle-loaded system for the controlled delivery of small hydrophobic drugs has been prepared using poly(¿-glutamic acid) (PGGA), a naturally occurring biopolymer made of glutamic acid units connected by amide linkages between a-amino and ¿-carboxylic acid groups, and poly(3,4-ethyl...

Descripción completa

Detalles Bibliográficos
Autores: Enshaei, Hamidreza, Puiggalí Jou, Anna|||0000-0002-2234-9436, Molina García, Brenda Guadalupe|||0000-0002-7723-5313, Saperas Plana, Núria|||0000-0002-5419-7502, Alemán Llansó, Carlos|||0000-0003-4462-6075
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/385240
Acceso en línea:https://hdl.handle.net/2117/385240
https://dx.doi.org/10.1016/j.eurpolymj.2022.111199
Access Level:acceso abierto
Palabra clave:Curcumin
Conducting polymers
Polythiophenes
Polyethylene
Electrostimulated release
Poly(3
4-ethylenedioxythiophene)
Poly(¿-glutamic acid)
Polímers conductors
Polietilè
Àrees temàtiques de la UPC::Enginyeria química
id ES_db0d7d6c87d5752ae1db6f6ee900413f
oai_identifier_str oai:upcommons.upc.edu:2117/385240
network_acronym_str ES
network_name_str España
repository_id_str
spelling Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugsEnshaei, HamidrezaPuiggalí Jou, Anna|||0000-0002-2234-9436Molina García, Brenda Guadalupe|||0000-0002-7723-5313Saperas Plana, Núria|||0000-0002-5419-7502Alemán Llansó, Carlos|||0000-0003-4462-6075CurcuminConducting polymersPolythiophenesPolyethyleneCurcuminElectrostimulated releasePoly(34-ethylenedioxythiophene)Poly(¿-glutamic acid)Polímers conductorsPolietilèÀrees temàtiques de la UPC::Enginyeria químicaA hydrogel/nanoparticle-loaded system for the controlled delivery of small hydrophobic drugs has been prepared using poly(¿-glutamic acid) (PGGA), a naturally occurring biopolymer made of glutamic acid units connected by amide linkages between a-amino and ¿-carboxylic acid groups, and poly(3,4-ethylenedioxythiophene) (PEDOT), a very stable conducting polymer with excellent electrochemical response. Specifically, curcumin (CUR)-loaded PEDOT nanoparticles (PEDOT/CUR) were incorporated to the PGGA hydrogel during the crosslinking reaction. After chemical, morphological and electrochemical characterization, the release profiles of PEDOT/CUR and PGGA/PEDOT/CUR system have been compared in absence and presence of electrical stimuli, which consisted on the application of a voltage of –0.5 V for 15 min every 24 h. Results show that the release is higher for electrically stimulated systems by more than twice, even though due to its hydrophobicity and poor solubility in water the release was relatively slow in both cases. This feature could be advantageous when the therapeutic treatment requires slow, controlled and sustained CUR release.Peer ReviewedElsevier20222022-06-0120232023-03-21journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/385240https://dx.doi.org/10.1016/j.eurpolymj.2022.111199reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3852402026-05-27T15:37:01Z
dc.title.none.fl_str_mv Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
title Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
spellingShingle Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
Enshaei, Hamidreza
Curcumin
Conducting polymers
Polythiophenes
Polyethylene
Curcumin
Electrostimulated release
Poly(3
4-ethylenedioxythiophene)
Poly(¿-glutamic acid)
Polímers conductors
Polietilè
Àrees temàtiques de la UPC::Enginyeria química
title_short Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
title_full Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
title_fullStr Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
title_full_unstemmed Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
title_sort Polypeptide hydrogel loaded with conducting polymer nanoparticles as electroresponsive delivery system of small hydrophobic drugs
dc.creator.none.fl_str_mv Enshaei, Hamidreza
Puiggalí Jou, Anna|||0000-0002-2234-9436
Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author Enshaei, Hamidreza
author_facet Enshaei, Hamidreza
Puiggalí Jou, Anna|||0000-0002-2234-9436
Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author_role author
author2 Puiggalí Jou, Anna|||0000-0002-2234-9436
Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Saperas Plana, Núria|||0000-0002-5419-7502
Alemán Llansó, Carlos|||0000-0003-4462-6075
author2_role author
author
author
author
dc.subject.none.fl_str_mv Curcumin
Conducting polymers
Polythiophenes
Polyethylene
Curcumin
Electrostimulated release
Poly(3
4-ethylenedioxythiophene)
Poly(¿-glutamic acid)
Polímers conductors
Polietilè
Àrees temàtiques de la UPC::Enginyeria química
topic Curcumin
Conducting polymers
Polythiophenes
Polyethylene
Curcumin
Electrostimulated release
Poly(3
4-ethylenedioxythiophene)
Poly(¿-glutamic acid)
Polímers conductors
Polietilè
Àrees temàtiques de la UPC::Enginyeria química
description A hydrogel/nanoparticle-loaded system for the controlled delivery of small hydrophobic drugs has been prepared using poly(¿-glutamic acid) (PGGA), a naturally occurring biopolymer made of glutamic acid units connected by amide linkages between a-amino and ¿-carboxylic acid groups, and poly(3,4-ethylenedioxythiophene) (PEDOT), a very stable conducting polymer with excellent electrochemical response. Specifically, curcumin (CUR)-loaded PEDOT nanoparticles (PEDOT/CUR) were incorporated to the PGGA hydrogel during the crosslinking reaction. After chemical, morphological and electrochemical characterization, the release profiles of PEDOT/CUR and PGGA/PEDOT/CUR system have been compared in absence and presence of electrical stimuli, which consisted on the application of a voltage of –0.5 V for 15 min every 24 h. Results show that the release is higher for electrically stimulated systems by more than twice, even though due to its hydrophobicity and poor solubility in water the release was relatively slow in both cases. This feature could be advantageous when the therapeutic treatment requires slow, controlled and sustained CUR release.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-01
2023
2023-03-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/385240
https://dx.doi.org/10.1016/j.eurpolymj.2022.111199
url https://hdl.handle.net/2117/385240
https://dx.doi.org/10.1016/j.eurpolymj.2022.111199
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869421639028965376
score 15,301603

Similares en LA Referencia