Therapeutic alternatives research for the treatment of ocular inflammatory diseases

In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribu...

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Detalles Bibliográficos
Autor: García Otero, Xurxo
Tipo de recurso: tesis doctoral
Fecha de publicación:2022
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/29914
Acceso en línea:http://hdl.handle.net/10347/29914
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimental
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spelling Therapeutic alternatives research for the treatment of ocular inflammatory diseasesGarcía Otero, XurxoMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentosMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentosMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimentalIn the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.Otero Espinar, Francisco JavierFernández Ferreiro, AnxoAguiar Fernández, PabloUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20222022-01-0120222022-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/29914reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/299142026-06-15T12:47:27Z
dc.title.none.fl_str_mv Therapeutic alternatives research for the treatment of ocular inflammatory diseases
title Therapeutic alternatives research for the treatment of ocular inflammatory diseases
spellingShingle Therapeutic alternatives research for the treatment of ocular inflammatory diseases
García Otero, Xurxo
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimental
title_short Therapeutic alternatives research for the treatment of ocular inflammatory diseases
title_full Therapeutic alternatives research for the treatment of ocular inflammatory diseases
title_fullStr Therapeutic alternatives research for the treatment of ocular inflammatory diseases
title_full_unstemmed Therapeutic alternatives research for the treatment of ocular inflammatory diseases
title_sort Therapeutic alternatives research for the treatment of ocular inflammatory diseases
dc.creator.none.fl_str_mv García Otero, Xurxo
author García Otero, Xurxo
author_facet García Otero, Xurxo
author_role author
dc.contributor.none.fl_str_mv Otero Espinar, Francisco Javier
Fernández Ferreiro, Anxo
Aguiar Fernández, Pablo
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimental
topic Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimental
description In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/29914
url http://hdl.handle.net/10347/29914
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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