Therapeutic alternatives research for the treatment of ocular inflammatory diseases
In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribu...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/29914 |
| Acceso en línea: | http://hdl.handle.net/10347/29914 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentos Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimental |
| Sumario: | In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems. |
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