Beta-lactams

Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Pe...

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Detalles Bibliográficos
Autores: Balsalobre, Luz, Blanco, Ana, Alarcón Cavero, Teresa
Tipo de recurso: capítulo de libro
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/738940
Acceso en línea:https://hdl.handle.net/10486/738940
https://dx.doi.org/10.1002/9781119282549.ch3
Access Level:acceso abierto
Palabra clave:penicillins
cephalosporins
monobactams
carbapenems
PBPs
betalactamases
carbapenemases
ceftazidime-avibactam
ceftolozane-tazobactam
ceftaroline
Medicina
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spelling Beta-lactamsBalsalobre, LuzBlanco, AnaAlarcón Cavero, TeresapenicillinscephalosporinsmonobactamscarbapenemsPBPsbetalactamasescarbapenemasesceftazidime-avibactamceftolozane-tazobactamceftarolineMedicinaBeta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (first-, second-, third-, fourth-, and fifth-generation), monobactams, carbapenems and the association of a beta-lactam with a beta-lactamase inhibitor (Beta-lactam and non-beta-lactam inhibitors). Carbapenems have a carbon atom instead of a sulfur or an oxygen atom in the bicyclic nucleus and a hydroxyethyl side chain in trans configuration at position 6 and are the widest spectrum antibiotics available among the beta-lactams. Beta-lactams are bactericidal agents that kill bacteria by inhibiting the synthesis of the cell wall in both Gram-negative and Gram-positive bacteria, interacting with PBPs, so the transpeptidation reaction is blockaded, leading to the cell lysis and death. As a consequence of the widespread use of this antibiotics, bacterial resistance is a growing problem in both community and hospital settings. Emergence and dissemination of beta-lactam resistance have renewed interest in the development of novel beta-lactam antibiotics or beta-lactamase inhibitors, and some of them are currently available for multi-resistant bacteria treatmentWileyCapelo Martínez, José LuisIgrejas, GilbertoDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20192019-08-23book parthttp://purl.org/coar/resource_type/c_3248AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/bookPartapplication/pdfhttps://hdl.handle.net/10486/738940https://dx.doi.org/10.1002/9781119282549.ch3reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7389402026-06-23T12:46:27Z
dc.title.none.fl_str_mv Beta-lactams
title Beta-lactams
spellingShingle Beta-lactams
Balsalobre, Luz
penicillins
cephalosporins
monobactams
carbapenems
PBPs
betalactamases
carbapenemases
ceftazidime-avibactam
ceftolozane-tazobactam
ceftaroline
Medicina
title_short Beta-lactams
title_full Beta-lactams
title_fullStr Beta-lactams
title_full_unstemmed Beta-lactams
title_sort Beta-lactams
dc.creator.none.fl_str_mv Balsalobre, Luz
Blanco, Ana
Alarcón Cavero, Teresa
author Balsalobre, Luz
author_facet Balsalobre, Luz
Blanco, Ana
Alarcón Cavero, Teresa
author_role author
author2 Blanco, Ana
Alarcón Cavero, Teresa
author2_role author
author
dc.contributor.none.fl_str_mv Capelo Martínez, José Luis
Igrejas, Gilberto
Departamento de Medicina Preventiva y Salud Pública y Microbiología
Facultad de Medicina
dc.subject.none.fl_str_mv penicillins
cephalosporins
monobactams
carbapenems
PBPs
betalactamases
carbapenemases
ceftazidime-avibactam
ceftolozane-tazobactam
ceftaroline
Medicina
topic penicillins
cephalosporins
monobactams
carbapenems
PBPs
betalactamases
carbapenemases
ceftazidime-avibactam
ceftolozane-tazobactam
ceftaroline
Medicina
description Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (first-, second-, third-, fourth-, and fifth-generation), monobactams, carbapenems and the association of a beta-lactam with a beta-lactamase inhibitor (Beta-lactam and non-beta-lactam inhibitors). Carbapenems have a carbon atom instead of a sulfur or an oxygen atom in the bicyclic nucleus and a hydroxyethyl side chain in trans configuration at position 6 and are the widest spectrum antibiotics available among the beta-lactams. Beta-lactams are bactericidal agents that kill bacteria by inhibiting the synthesis of the cell wall in both Gram-negative and Gram-positive bacteria, interacting with PBPs, so the transpeptidation reaction is blockaded, leading to the cell lysis and death. As a consequence of the widespread use of this antibiotics, bacterial resistance is a growing problem in both community and hospital settings. Emergence and dissemination of beta-lactam resistance have renewed interest in the development of novel beta-lactam antibiotics or beta-lactamase inhibitors, and some of them are currently available for multi-resistant bacteria treatment
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-08-23
dc.type.none.fl_str_mv book part
http://purl.org/coar/resource_type/c_3248
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/738940
https://dx.doi.org/10.1002/9781119282549.ch3
url https://hdl.handle.net/10486/738940
https://dx.doi.org/10.1002/9781119282549.ch3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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