Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography

18 pags, 11 figs, 5 tabs

Detalles Bibliográficos
Autores:	Pandey, Suraj, Calvey, George, Katz, Andrea M., Malla, Tek Narsingh, Koua, Faisal H. M., Martín-García, José M., Poudyal, Ishwor, Yang, Jay-How, Vakili, Mohammad, Yefanov, Oleksandr, Zielinski, Kara A., Bajt, Sasa, Awel, Salah, Doerner, Katarina, Frank, Matthias, Gelisio, Luca, Jernigan, Rebecca, Kirkwood, Henry, Kloos, Marco, Koliyadu, Jayanath, Mariani, Valerio, Miller, Mitchell D., Mills, Grant, Nelson, Garrett, Olmos, Jose L., Sadri, Alireza, Sato, Tokushi, Tolstikova, Alexandra, Xu, Weijun, Ourmazd, Abbas, Spence, John C. H., Schwander, Peter, Barty, Anton, Chapman, Henry N., Fromme, Petra, Mancuso, Adrian P., Phillips, George N., Bean, Richard, Pollack, Lois, Schmidt, Marius
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/258729
Acceso en línea:	http://hdl.handle.net/10261/258729 https://api.elsevier.com/content/abstract/scopus_id/85118931472
Access Level:	acceso abierto
Palabra clave:	European X-ray Free-Electron Laser X-ray crystallography Antibiotic resistance Ceftriaxone Drug discovery Enzyme kinetics Enzyme mechanisms Irreversible inhibition Megahertz pulse-repetition rate Mix-and-inject serial crystallography Protein structure determination Serial femtosecond crystallography Substrate diffusion in crystals Sulbactam β-lactamases

Descripción
Sumario:	18 pags, 11 figs, 5 tabs