Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct

Background and Purpose: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correla...

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Autores: Sozzi, Caterina, Brenlla, Carla, Bartolomé, Inés, Girona, Andrés, Muñoz-Moreno, Emma, Laredo, Carlos, Rodríguez-Vázquez, Alejandro, Doncel-Moriano, Antonio, Rudilosso, Salvatore, Chamorro, Ángel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/71974
Acesso em linha:http://hdl.handle.net/10230/71974
http://dx.doi.org/10.3390/jcdd11110345
Access Level:acceso abierto
Palavra-chave:Cerebral small vessel disease
Lacunar stroke
Perivascular spaces
Sleep
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spelling Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarctSozzi, CaterinaBrenlla, CarlaBartolomé, InésGirona, AndrésMuñoz-Moreno, EmmaLaredo, CarlosRodríguez-Vázquez, AlejandroDoncel-Moriano, AntonioRudilosso, SalvatoreChamorro, ÁngelCerebral small vessel diseaseLacunar strokePerivascular spacesSleepBackground and Purpose: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correlation with clinical and imaging factors. Materials and Methods: In a cohort of 71 patients with an RSSI with complete clinical data, including the Pittsburgh Sleep Quality Index (PSQI), we segmented PVS in white matter (WM-PVS), basal ganglia (BG-PVS), and brainstems (BS-PVS) on 3T-MRI T2-weighted sequences, obtaining fractional volumes (%), and calculated the WM/BG-PVS ratio. We analyzed the Pearson’s correlation coefficients between PVS regional loads. We used normalized PVS measures to assess the associations with clinical and MRI-SVD features (white matter hyperintensities (WMHs), number of lacunes, and microbleeds) in univariable and multivariable linear regressions adjusted for age, sex, and hypertension. Results: In our cohort (mean age 70 years; 27% female), the Pearson’s correlation coefficients between WM-PVS/BG-PVS, WM-PVS/BS-PVS, and BG-PVS/BS-PVS were 0.67, 0.61, and 0.59 (all p < 0.001). In the adjusted models, BG-PVS were associated with lacunes (p = 0.034), WMHs (p = 0.006), and microbleeds (p = 0.017); WM-PVS with lacunes (p = 0.003); while BS-PVS showed no associations. The WM/BG-PVS ratio was associated with lacunes (p = 0.018) and the PSQI (p = 0.046). Conclusions: PVS burdens in different regions are highly correlated in patients with RSSI but with different SVD patterns. Sleep quality impairment might affect waste removal mechanisms differently in the WM and BG regions.MDPI202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71974http://dx.doi.org/10.3390/jcdd11110345http://hdl.handle.net/10230/71974reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Cardiovascular Development and Disease. 2024;11(11):345© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/719742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
title Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
spellingShingle Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
Sozzi, Caterina
Cerebral small vessel disease
Lacunar stroke
Perivascular spaces
Sleep
title_short Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
title_full Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
title_fullStr Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
title_full_unstemmed Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
title_sort Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct
dc.creator.none.fl_str_mv Sozzi, Caterina
Brenlla, Carla
Bartolomé, Inés
Girona, Andrés
Muñoz-Moreno, Emma
Laredo, Carlos
Rodríguez-Vázquez, Alejandro
Doncel-Moriano, Antonio
Rudilosso, Salvatore
Chamorro, Ángel
author Sozzi, Caterina
author_facet Sozzi, Caterina
Brenlla, Carla
Bartolomé, Inés
Girona, Andrés
Muñoz-Moreno, Emma
Laredo, Carlos
Rodríguez-Vázquez, Alejandro
Doncel-Moriano, Antonio
Rudilosso, Salvatore
Chamorro, Ángel
author_role author
author2 Brenlla, Carla
Bartolomé, Inés
Girona, Andrés
Muñoz-Moreno, Emma
Laredo, Carlos
Rodríguez-Vázquez, Alejandro
Doncel-Moriano, Antonio
Rudilosso, Salvatore
Chamorro, Ángel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cerebral small vessel disease
Lacunar stroke
Perivascular spaces
Sleep
topic Cerebral small vessel disease
Lacunar stroke
Perivascular spaces
Sleep
description Background and Purpose: Perivascular spaces (PVS) are usually enlarged in small vessel disease (SVD). However, the significance of PVS patterns in different locations is uncertain. Hence, we analyzed the distribution of PVS in patients with a recent small subcortical infarct (RSSI) and their correlation with clinical and imaging factors. Materials and Methods: In a cohort of 71 patients with an RSSI with complete clinical data, including the Pittsburgh Sleep Quality Index (PSQI), we segmented PVS in white matter (WM-PVS), basal ganglia (BG-PVS), and brainstems (BS-PVS) on 3T-MRI T2-weighted sequences, obtaining fractional volumes (%), and calculated the WM/BG-PVS ratio. We analyzed the Pearson’s correlation coefficients between PVS regional loads. We used normalized PVS measures to assess the associations with clinical and MRI-SVD features (white matter hyperintensities (WMHs), number of lacunes, and microbleeds) in univariable and multivariable linear regressions adjusted for age, sex, and hypertension. Results: In our cohort (mean age 70 years; 27% female), the Pearson’s correlation coefficients between WM-PVS/BG-PVS, WM-PVS/BS-PVS, and BG-PVS/BS-PVS were 0.67, 0.61, and 0.59 (all p < 0.001). In the adjusted models, BG-PVS were associated with lacunes (p = 0.034), WMHs (p = 0.006), and microbleeds (p = 0.017); WM-PVS with lacunes (p = 0.003); while BS-PVS showed no associations. The WM/BG-PVS ratio was associated with lacunes (p = 0.018) and the PSQI (p = 0.046). Conclusions: PVS burdens in different regions are highly correlated in patients with RSSI but with different SVD patterns. Sleep quality impairment might affect waste removal mechanisms differently in the WM and BG regions.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71974
http://dx.doi.org/10.3390/jcdd11110345
http://hdl.handle.net/10230/71974
url http://hdl.handle.net/10230/71974
http://dx.doi.org/10.3390/jcdd11110345
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Cardiovascular Development and Disease. 2024;11(11):345
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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