A Search for New Biological Pathways in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy by Proteomic Research

[Background/Objectives] Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary small vessel disease leading to significant morbidity and mortality. Despite advances in genetic diagnosis, the underlying pathophysiology remains incompletely...

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Detalles Bibliográficos
Autores: Menéndez-Valladares, Paloma, Acevedo Aguilera, Rosa, Núñez Jurado, David, López Azcárate, Cristina, Domínguez-Mayoral, Ana, Fernández-Vega, Alejandro, Pérez-Sánchez, Soledad, Lamana-Vallverdú, Marcel, García-Sánchez, María Isabel, Morales Bravo, María, Busquier Cerdán, Teresa, Montaner, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/371238
Acceso en línea:http://hdl.handle.net/10261/371238
https://api.elsevier.com/content/abstract/scopus_id/85195860770
Access Level:acceso abierto
Palabra clave:Stroke
CADASIL
Biomarkers
Proteomics
Small vessel disease
Descripción
Sumario:[Background/Objectives] Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary small vessel disease leading to significant morbidity and mortality. Despite advances in genetic diagnosis, the underlying pathophysiology remains incompletely understood. Proteomic studies offer insights into disease mechanisms by identifying altered protein expression patterns. Here, we conducted a proteomic analysis to elucidate molecular pathways associated with CADASIL.

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