Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts

Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the con...

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Detalhes bibliográficos
Autores: Anacleto-Santos, Jhony, Vega-Ávila, Elisa, Pacheco, Leticia, Lacueva-Arnedo, Manuel, Gómez Barrio, Alicia, Ibáñez Escribano, Alexandra, López-Pérez, Teresa de Jesús, Casarrubias-Tabarez, Brenda, Calzada, Fernando, López-Camacho, Perla Yolanda, Rivera-Fernández, Norma
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104299
Acesso em linha:https://hdl.handle.net/20.500.14352/104299
Access Level:acceso abierto
Palavra-chave:579.6
615.28
576.8
traditional medicine
antibacterial activity
trichomonacidal effect
Pleopeltis crassinervata
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
3209 Farmacología
Descrição
Resumo:Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from P. crassinervata organs against bacteria (Salmonella typhimurium, Salmonella typhi, Staphylococcus aureus, Proteus mirabilis, Shigella flexneri, Bacillus subtilis, Escherichia coli) and Trichomonas vaginalis using in vitro models. The precipitate fraction obtained from the frond methanolic extract showed significant antibacterial activity (minimal inhibitory concentration [MIC] 120 µg/mL) against the Staphylococcus aureus strain and was effective against both Gram-positive and Gram-negative bacteria. The hexane fraction also obtained from frond methanolic extract, showed a trichomonacidal effect with an IC50 of 82.8 μg/mL and a low cytotoxic effect. Hsf6 exhibited the highest activity against T. vaginalis, and the GC-MS analysis revealed that the predominant compound was 16-pregnenolone. The remaining identified compounds were primarily terpene-type compounds.

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