Gammadelta T cells as a predictor of surgical relapse of Crohn's disease
Background: We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD pati...
| Autores: | , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositório: | Docta Complutense |
| Idioma: | inglês |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/101541 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/101541 |
| Access Level: | Acceso aberto |
| Palavra-chave: | 579.6 615.28 576.8 Crohn’s Disease Gammadelta T cells Surgery Relapse Ciencias Biomédicas Microbiología (Farmacia) Parasitología (Farmacia) 3207.10 Inmunopatología |
| Resumo: | Background: We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD patients. The aim of this study is to study the correlation between αβ and γδ T cell subsets in the peripheral blood of patients with CD and the risk for surgery during follow up. Methods: A prospective study of 102 patients with CD compared with 102 healthy subjects (control group) matched by age and sex was conducted. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, and αβ and γδ T cell subsets were measured in the peripheral blood of all participants. Results: We found evidence of a relationship between lower γδ T cell levels and risk of surgical relapse in CD. The lowest subsets observed in CD patients with surgical relapse were CD3 + γδ, CD3 + CD8 + γδ and CD3 + CD56 + γδ T cells. We observed a relationship between a decrease in γδ T cells and the most severe forms of the disease. The lowest levels of CD3 + γδ and CD3 + CD8 + γδ T cells were observed in the fistulizing phenotype. Conclusions: The deficit of γδ T cells was related with the severity and the risk for surgicalrelapse in CD patients. Patients with CD3 + γδ deficit were more prone to surgery than patientswithout this deficit. These results suggest that γδ T cells could be used as markers of poorprognosis of CD following the diagnosis of the disease. |
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