Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

Carbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate e...

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Detalles Bibliográficos
Autores: Díaz Díaz, David, Maiti, Binoy, Ng, Gervase, Abramov, Alex, Boyer, Cyrille
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de La Laguna (ULL)
Repositorio:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/42194
Acceso en línea:http://riull.ull.es/xmlui/handle/915/42194
Access Level:acceso abierto
Palabra clave:carbon monoxide
polymer
biofilm
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spelling Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formationDíaz Díaz, DavidMaiti, BinoyNg, GervaseAbramov, AlexBoyer, Cyrillecarbon monoxidepolymerbiofilmCarbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate equipment for delivery. A wellknown and most studied carbon monoxide releasing molecule (CORM) is tricarbonyldichlororuthenium(II) dimer (Ru2Cl4(CO)6). However, its use as a therapeutic agent is restricted due to its poor water solubility and a short half-life. In order to solve this issues we have designed and synthesized a water-soluble methionine (methionine methacryloyloxyethyl ester (METMA)) and poly(ethylene glycol methyl ether methacrylate) containing block-copolymer via reversible addition–fragmentation chain transfer (RAFT) polymerization and attached the CORM in the methionine side chain units. Inductively coupled plasma optical emission spectrometry (ICP-OES) and FT-IR confirms the presence of CORM molecule into the polymer. The time-dependent CO release from CORM conjugated block-copolymer was investigated by a myoglobin assay. This CORM conjugated block-copolymer slowly and spontaneously released CO with sustained-release kinetics. Moreover, this CO-releasing polymer was able to prevent biofilm formation against Pseudomonas aeruginosa.Royal Society of Chemistry202520252021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://riull.ull.es/xmlui/handle/915/42194reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésPolymer Chemistry;12, 2021info:eu-repo/semantics/openAccessoai:riull.ull.es:915/421942026-06-22T13:13:57Z
dc.title.none.fl_str_mv Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
title Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
spellingShingle Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
Díaz Díaz, David
carbon monoxide
polymer
biofilm
title_short Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
title_full Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
title_fullStr Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
title_full_unstemmed Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
title_sort Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation
dc.creator.none.fl_str_mv Díaz Díaz, David
Maiti, Binoy
Ng, Gervase
Abramov, Alex
Boyer, Cyrille
author Díaz Díaz, David
author_facet Díaz Díaz, David
Maiti, Binoy
Ng, Gervase
Abramov, Alex
Boyer, Cyrille
author_role author
author2 Maiti, Binoy
Ng, Gervase
Abramov, Alex
Boyer, Cyrille
author2_role author
author
author
author
dc.subject.none.fl_str_mv carbon monoxide
polymer
biofilm
topic carbon monoxide
polymer
biofilm
description Carbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate equipment for delivery. A wellknown and most studied carbon monoxide releasing molecule (CORM) is tricarbonyldichlororuthenium(II) dimer (Ru2Cl4(CO)6). However, its use as a therapeutic agent is restricted due to its poor water solubility and a short half-life. In order to solve this issues we have designed and synthesized a water-soluble methionine (methionine methacryloyloxyethyl ester (METMA)) and poly(ethylene glycol methyl ether methacrylate) containing block-copolymer via reversible addition–fragmentation chain transfer (RAFT) polymerization and attached the CORM in the methionine side chain units. Inductively coupled plasma optical emission spectrometry (ICP-OES) and FT-IR confirms the presence of CORM molecule into the polymer. The time-dependent CO release from CORM conjugated block-copolymer was investigated by a myoglobin assay. This CORM conjugated block-copolymer slowly and spontaneously released CO with sustained-release kinetics. Moreover, this CO-releasing polymer was able to prevent biofilm formation against Pseudomonas aeruginosa.
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/42194
url http://riull.ull.es/xmlui/handle/915/42194
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Polymer Chemistry;12, 2021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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