Carbon-Monoxide-Releasing Molecules for the Delivery of Therapeutic CO In Vivo
The development of carbon-monoxide-releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition-metal carbonyl complexes. Although such CORMs have showed promising results in the treat...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/67699 |
| Acceso en línea: | http://hdl.handle.net/10017/67699 https://dx.doi.org/10.1002/anie.201311225 |
| Access Level: | acceso abierto |
| Palabra clave: | Bioinorganic chemistry Carbon monoxide Drug delivery Photochemistry Transition metals Química Chemistry |
| Sumario: | The development of carbon-monoxide-releasing molecules (CORMs) as pharmaceutical agents represents an attractive and safer alternative to administration of gaseous CO. Most CORMs developed to date are transition-metal carbonyl complexes. Although such CORMs have showed promising results in the treatment of a number of animal models of disease, they still lack the necessary attributes for clinical development. Described in this Minireview are the methods used for CORM selection, to date, and how new insights into the reactivity of metal-carbonyl complexes in?vivo, together with advances in methods for live-cell CO detection, are driving the design and synthesis of new CORMs, CORMs that will enable controlled CO release in?vivo in a spatial and temporal manner without affecting oxygen transport by hemoglobin. |
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