Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:296591 |
| Acceso en línea: | https://ddd.uab.cat/record/296591 https://dx.doi.org/urn:doi:10.3390/pathogens12121403 |
| Access Level: | acceso abierto |
| Palabra clave: | Contact tracing Epidemiology Latent tuberculosis infection Tuberculosis |
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Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact StudiesGodoy, SofiaParrón, Ignacio|||0000-0002-4875-0236Millet, Joan Pau|||0000-0003-0200-2459Caylà, Joan A.|||0000-0003-3891-111XFollia, NúriaCarol Torrades, MonicaOrcau, Àngels|||0000-0001-8109-7614Alsedà, Miquel|||0000-0003-4008-3616Toledo, Diana|||0000-0003-0794-9238Ferrús, GlòriaPlans, PereBarrabeig, Irene|||0000-0003-4789-7620Clotet Romero, Laura|||0000-0001-9522-7870Domínguez, Ángela|||0000-0003-0219-1907Godoy, Pere|||0000-0002-2896-7286Ros, Miriam|||0000-0002-3659-8222Sabater-Lleal, Maria|||0000-0002-0128-379XContact tracingEpidemiologyLatent tuberculosis infectionTuberculosisThe control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age ≥65 years (aOR = 0.3; 95%CI: 0.2-0.6) and a daily exposure of ≥6 h to the TB index case (aOR = 3.6; 95%CI: 2.6-5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5-1.0) and immigrants (aOR = 0.7; 95%CI: 0.5-0.9). Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296591https://dx.doi.org/urn:doi:10.3390/pathogens12121403reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01751open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2965912026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| title |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| spellingShingle |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies Godoy, Sofia Contact tracing Epidemiology Latent tuberculosis infection Tuberculosis |
| title_short |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| title_full |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| title_fullStr |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| title_full_unstemmed |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| title_sort |
Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies |
| dc.creator.none.fl_str_mv |
Godoy, Sofia Parrón, Ignacio|||0000-0002-4875-0236 Millet, Joan Pau|||0000-0003-0200-2459 Caylà, Joan A.|||0000-0003-3891-111X Follia, Núria Carol Torrades, Monica Orcau, Àngels|||0000-0001-8109-7614 Alsedà, Miquel|||0000-0003-4008-3616 Toledo, Diana|||0000-0003-0794-9238 Ferrús, Glòria Plans, Pere Barrabeig, Irene|||0000-0003-4789-7620 Clotet Romero, Laura|||0000-0001-9522-7870 Domínguez, Ángela|||0000-0003-0219-1907 Godoy, Pere|||0000-0002-2896-7286 Ros, Miriam|||0000-0002-3659-8222 Sabater-Lleal, Maria|||0000-0002-0128-379X |
| author |
Godoy, Sofia |
| author_facet |
Godoy, Sofia Parrón, Ignacio|||0000-0002-4875-0236 Millet, Joan Pau|||0000-0003-0200-2459 Caylà, Joan A.|||0000-0003-3891-111X Follia, Núria Carol Torrades, Monica Orcau, Àngels|||0000-0001-8109-7614 Alsedà, Miquel|||0000-0003-4008-3616 Toledo, Diana|||0000-0003-0794-9238 Ferrús, Glòria Plans, Pere Barrabeig, Irene|||0000-0003-4789-7620 Clotet Romero, Laura|||0000-0001-9522-7870 Domínguez, Ángela|||0000-0003-0219-1907 Godoy, Pere|||0000-0002-2896-7286 Ros, Miriam|||0000-0002-3659-8222 Sabater-Lleal, Maria|||0000-0002-0128-379X |
| author_role |
author |
| author2 |
Parrón, Ignacio|||0000-0002-4875-0236 Millet, Joan Pau|||0000-0003-0200-2459 Caylà, Joan A.|||0000-0003-3891-111X Follia, Núria Carol Torrades, Monica Orcau, Àngels|||0000-0001-8109-7614 Alsedà, Miquel|||0000-0003-4008-3616 Toledo, Diana|||0000-0003-0794-9238 Ferrús, Glòria Plans, Pere Barrabeig, Irene|||0000-0003-4789-7620 Clotet Romero, Laura|||0000-0001-9522-7870 Domínguez, Ángela|||0000-0003-0219-1907 Godoy, Pere|||0000-0002-2896-7286 Ros, Miriam|||0000-0002-3659-8222 Sabater-Lleal, Maria|||0000-0002-0128-379X |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Contact tracing Epidemiology Latent tuberculosis infection Tuberculosis |
| topic |
Contact tracing Epidemiology Latent tuberculosis infection Tuberculosis |
| description |
The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age ≥65 years (aOR = 0.3; 95%CI: 0.2-0.6) and a daily exposure of ≥6 h to the TB index case (aOR = 3.6; 95%CI: 2.6-5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5-1.0) and immigrants (aOR = 0.7; 95%CI: 0.5-0.9). Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/296591 https://dx.doi.org/urn:doi:10.3390/pathogens12121403 |
| url |
https://ddd.uab.cat/record/296591 https://dx.doi.org/urn:doi:10.3390/pathogens12121403 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01751 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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