Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks

The study of complex systems has unraveled the basic principles underlying the emergence of collective behaviors in networks of interacting units. Following this framework, we suggest that excitatory-inhibitory balance is one of such principles in cortical networks. We start by revealing how balance...

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Autor: Páscoa dos Santos, Francisco
Formato: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/692219
Acesso em linha:http://hdl.handle.net/10803/692219
Access Level:acceso embargado
Palavra-chave:Excitatory-inhibitory balance
Cortical networks
62
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spelling Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networksPáscoa dos Santos, FranciscoExcitatory-inhibitory balanceCortical networks62The study of complex systems has unraveled the basic principles underlying the emergence of collective behaviors in networks of interacting units. Following this framework, we suggest that excitatory-inhibitory balance is one of such principles in cortical networks. We start by revealing how balanced excitatory-inhibitory interactions shape empirical functional networks and dynamics, especially at ultra-slow timescales. Then, we demonstrate the potential of excitatory-inhibitory homeostasis as a mechanism of self-organization by studying its role in the re-emergence of functional networks following lesions, reconciling empirical findings on the connectivity and excitability of the post-stroke brain. Finally, we demonstrate how multiple modes of homeostasis cooperate to support the emergence of collective metastable dynamics, maximizing functional complexity in large-scale cortical networks. Altogether, our results show that the benefits of maintaining a balance between excitation and inhibition extravasate the neuronal level, being a key piece in the emergence of collective dynamics in large-scale cortical networks.L’estudi dels sistemes complexos ha desvelat els principis bàsics subjacents a l’emergència de comportaments col·lectius en xarxes d’unitats que interactuen. Seguint aquests fonaments, en aquesta tesi suggerim que l’equilibri excitatori-inhibitori és un d’aquests principis a les xarxes corticals. Comencem revelant com l’equilibri de interaccions excitatòries-inhibitòries dona forma a les dinàmiques i xarxes funcionals empíriques, especialment a escales de temps ultra lentes. A continuació, demostrem el potencial de l’homeòstasi excitatòria-inhibitòria com a mecanisme d’auto-organització a través de l’estudi del seu paper en la re-emergència de les xarxes funcionals després de lesions, conciliant el coneixement empíric sobre la connectivitat i l’excitabilitat del cervell post-ictus. Finalment, demostrem com múltiples modes d’homeòstasi cooperen per donar suport a l’emergència de dinàmiques col·lectives metaestables, maximitzant la complexitat funcional en xarxes corticals. Així, els nostres resultats demostren que els beneficis de mantenir l’equilibri entre excitació i inhibició extravasen el nivell neuronal, sent una pec¸a clau en l’emergència de dinàmiques col·lectives en xarxes corticals de llarga escala.Programa de Doctorat en Tecnologies de la Informació i les ComunicacionsUniversitat Pompeu FabraVerschure, Paul F.M.J.Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions202420242026info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion342 p.application/pdfhttp://hdl.handle.net/10803/692219TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:www.tdx.cat:10803/6922192026-06-14T12:46:07Z
dc.title.none.fl_str_mv Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
title Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
spellingShingle Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
Páscoa dos Santos, Francisco
Excitatory-inhibitory balance
Cortical networks
62
title_short Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
title_full Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
title_fullStr Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
title_full_unstemmed Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
title_sort Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
dc.creator.none.fl_str_mv Páscoa dos Santos, Francisco
author Páscoa dos Santos, Francisco
author_facet Páscoa dos Santos, Francisco
author_role author
dc.contributor.none.fl_str_mv Verschure, Paul F.M.J.
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
dc.subject.none.fl_str_mv Excitatory-inhibitory balance
Cortical networks
62
topic Excitatory-inhibitory balance
Cortical networks
62
description The study of complex systems has unraveled the basic principles underlying the emergence of collective behaviors in networks of interacting units. Following this framework, we suggest that excitatory-inhibitory balance is one of such principles in cortical networks. We start by revealing how balanced excitatory-inhibitory interactions shape empirical functional networks and dynamics, especially at ultra-slow timescales. Then, we demonstrate the potential of excitatory-inhibitory homeostasis as a mechanism of self-organization by studying its role in the re-emergence of functional networks following lesions, reconciling empirical findings on the connectivity and excitability of the post-stroke brain. Finally, we demonstrate how multiple modes of homeostasis cooperate to support the emergence of collective metastable dynamics, maximizing functional complexity in large-scale cortical networks. Altogether, our results show that the benefits of maintaining a balance between excitation and inhibition extravasate the neuronal level, being a key piece in the emergence of collective dynamics in large-scale cortical networks.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/692219
url http://hdl.handle.net/10803/692219
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv 342 p.
application/pdf
dc.publisher.none.fl_str_mv Universitat Pompeu Fabra
publisher.none.fl_str_mv Universitat Pompeu Fabra
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
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