Striking a balance global impact of the local regulation of excitatory-inhibitory balance in cortical networks
The study of complex systems has unraveled the basic principles underlying the emergence of collective behaviors in networks of interacting units. Following this framework, we suggest that excitatory-inhibitory balance is one of such principles in cortical networks. We start by revealing how balance...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/692219 |
| Acceso en línea: | http://hdl.handle.net/10803/692219 |
| Access Level: | acceso embargado |
| Palabra clave: | Excitatory-inhibitory balance Cortical networks 62 |
| Sumario: | The study of complex systems has unraveled the basic principles underlying the emergence of collective behaviors in networks of interacting units. Following this framework, we suggest that excitatory-inhibitory balance is one of such principles in cortical networks. We start by revealing how balanced excitatory-inhibitory interactions shape empirical functional networks and dynamics, especially at ultra-slow timescales. Then, we demonstrate the potential of excitatory-inhibitory homeostasis as a mechanism of self-organization by studying its role in the re-emergence of functional networks following lesions, reconciling empirical findings on the connectivity and excitability of the post-stroke brain. Finally, we demonstrate how multiple modes of homeostasis cooperate to support the emergence of collective metastable dynamics, maximizing functional complexity in large-scale cortical networks. Altogether, our results show that the benefits of maintaining a balance between excitation and inhibition extravasate the neuronal level, being a key piece in the emergence of collective dynamics in large-scale cortical networks. |
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