Wireless Nanobioelectronics for Electrical Intracellular Sensing

Sanjuán Alberte, Paola; Jain, Akhil; Shaw, Andie J.; Abayzeed, Sidahmed A.; Fuentes Domínguez, Rafael; Alea Reyes, María Elisa; Clark, Matt; Alexander, Morgan R.; Hague, Richard J. M.; Pérez García, M. Lluïsa (Maria Lluïsa); Rawson, Frankie J.

Wireless Nanobioelectronics for Electrical Intracellular Sensing

For the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of "wireless" electronic systems to enable modulation of chemistry inside of cells. Herein we report on an intracellular wireless electronic communication system. This is bas...

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Detalles Bibliográficos
Autores:	Sanjuán Alberte, Paola, Jain, Akhil, Shaw, Andie J., Abayzeed, Sidahmed A., Fuentes Domínguez, Rafael, Alea Reyes, María Elisa, Clark, Matt, Alexander, Morgan R., Hague, Richard J. M., Pérez García, M. Lluïsa (Maria Lluïsa), Rawson, Frankie J.
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2019
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/162465
Acceso en línea:	https://hdl.handle.net/2445/162465
Access Level:	acceso abierto
Palabra clave:	Bioelectrònica Electroquímica Nanotecnologia Porfirines Xarxes de sensors sense fil Bioelectronics Electrochemistry Nanotechnology Porphyrins Wireless sensor networks

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spelling	Wireless Nanobioelectronics for Electrical Intracellular SensingSanjuán Alberte, PaolaJain, AkhilShaw, Andie J.Abayzeed, Sidahmed A.Fuentes Domínguez, RafaelAlea Reyes, María ElisaClark, MattAlexander, Morgan R.Hague, Richard J. M.Pérez García, M. Lluïsa (Maria Lluïsa)Rawson, Frankie J.BioelectrònicaElectroquímicaNanotecnologiaPorfirinesXarxes de sensors sense filBioelectronicsElectrochemistryNanotechnologyPorphyrinsWireless sensor networksFor the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of "wireless" electronic systems to enable modulation of chemistry inside of cells. Herein we report on an intracellular wireless electronic communication system. This is based on modulating the electrochemistry on gold nanoparticles without the nanoparticles having any physical electrical connection to a power supply at relatively low externally applied potentials. The system is made functional by modifying water-soluble gold nanoparticles (ws-AuNPs) with a Zn(II) meso-tetrakis(4-carboxyphenyl)porphyrin sodium salt (Na-ZnTCPP). Na-ZnTCPP modified ws-AuNPs are taken up by cells and are shown to be noncytotoxic. It is demonstrated that the redox state of the Zn-porphyrin modified gold nanoparticles is controlled, and a fluorescent output can be used to measure this during the application of an external electrical potential. When the porphyrin modified nanoparticles were located intracellularly and external potentials were applied, the same effect was observed. This provides an attractive "wireless" approach to develop bioelectronic devices for modulating and sensing cellular behavior.ACS Publications2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion12 p.application/pdfhttps://hdl.handle.net/2445/162465Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1021/acsanm.9b01374ACS Applied Nano Materials, 2019, vol. 2, p. 6397-6408https://doi.org/10.1021/acsanm.9b01374(c) ACS Publications, 2019info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1624652026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Wireless Nanobioelectronics for Electrical Intracellular Sensing
title	Wireless Nanobioelectronics for Electrical Intracellular Sensing
spellingShingle	Wireless Nanobioelectronics for Electrical Intracellular Sensing Sanjuán Alberte, Paola Bioelectrònica Electroquímica Nanotecnologia Porfirines Xarxes de sensors sense fil Bioelectronics Electrochemistry Nanotechnology Porphyrins Wireless sensor networks
title_short	Wireless Nanobioelectronics for Electrical Intracellular Sensing
title_full	Wireless Nanobioelectronics for Electrical Intracellular Sensing
title_fullStr	Wireless Nanobioelectronics for Electrical Intracellular Sensing
title_full_unstemmed	Wireless Nanobioelectronics for Electrical Intracellular Sensing
title_sort	Wireless Nanobioelectronics for Electrical Intracellular Sensing
dc.creator.none.fl_str_mv	Sanjuán Alberte, Paola Jain, Akhil Shaw, Andie J. Abayzeed, Sidahmed A. Fuentes Domínguez, Rafael Alea Reyes, María Elisa Clark, Matt Alexander, Morgan R. Hague, Richard J. M. Pérez García, M. Lluïsa (Maria Lluïsa) Rawson, Frankie J.
author	Sanjuán Alberte, Paola
author_facet	Sanjuán Alberte, Paola Jain, Akhil Shaw, Andie J. Abayzeed, Sidahmed A. Fuentes Domínguez, Rafael Alea Reyes, María Elisa Clark, Matt Alexander, Morgan R. Hague, Richard J. M. Pérez García, M. Lluïsa (Maria Lluïsa) Rawson, Frankie J.
author_role	author
author2	Jain, Akhil Shaw, Andie J. Abayzeed, Sidahmed A. Fuentes Domínguez, Rafael Alea Reyes, María Elisa Clark, Matt Alexander, Morgan R. Hague, Richard J. M. Pérez García, M. Lluïsa (Maria Lluïsa) Rawson, Frankie J.
author2_role	author author author author author author author author author author
dc.subject.none.fl_str_mv	Bioelectrònica Electroquímica Nanotecnologia Porfirines Xarxes de sensors sense fil Bioelectronics Electrochemistry Nanotechnology Porphyrins Wireless sensor networks
topic	Bioelectrònica Electroquímica Nanotecnologia Porfirines Xarxes de sensors sense fil Bioelectronics Electrochemistry Nanotechnology Porphyrins Wireless sensor networks
description	For the field of bioelectronics to make an impact on healthcare, there is an urgent requirement for the development of "wireless" electronic systems to enable modulation of chemistry inside of cells. Herein we report on an intracellular wireless electronic communication system. This is based on modulating the electrochemistry on gold nanoparticles without the nanoparticles having any physical electrical connection to a power supply at relatively low externally applied potentials. The system is made functional by modifying water-soluble gold nanoparticles (ws-AuNPs) with a Zn(II) meso-tetrakis(4-carboxyphenyl)porphyrin sodium salt (Na-ZnTCPP). Na-ZnTCPP modified ws-AuNPs are taken up by cells and are shown to be noncytotoxic. It is demonstrated that the redox state of the Zn-porphyrin modified gold nanoparticles is controlled, and a fluorescent output can be used to measure this during the application of an external electrical potential. When the porphyrin modified nanoparticles were located intracellularly and external potentials were applied, the same effect was observed. This provides an attractive "wireless" approach to develop bioelectronic devices for modulating and sensing cellular behavior.
publishDate	2019
dc.date.none.fl_str_mv	2019 2020 2020 2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/162465
url	https://hdl.handle.net/2445/162465
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1021/acsanm.9b01374 ACS Applied Nano Materials, 2019, vol. 2, p. 6397-6408 https://doi.org/10.1021/acsanm.9b01374
dc.rights.none.fl_str_mv	(c) ACS Publications, 2019 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) ACS Publications, 2019
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	12 p. application/pdf
dc.publisher.none.fl_str_mv	ACS Publications
publisher.none.fl_str_mv	ACS Publications
dc.source.none.fl_str_mv	Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Wireless Nanobioelectronics for Electrical Intracellular Sensing

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