Ready Access to the Echinopines Skeleton via Gold(I)-Catalyzed Alkoxycyclizations of Enynes
The [3,5,5,7] tetracyclic skeleton of echinopines has been stereo- selectively accessed through a gold(I)-catalyzed alkoxycyclization of cyclopropyl- tethered 1,6-enynes. The key bicyclo[4.2.1]nonane core of the enyne precursors was readily assembled by means of a Co-catalyzed [6 + 2] cycloaddition....
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/334735 |
| Acceso en línea: | http://hdl.handle.net/2072/334735 https://doi.org/10.1021/acs.joc.6b01607 |
| Access Level: | acceso abierto |
| Palabra clave: | 53 |
| Sumario: | The [3,5,5,7] tetracyclic skeleton of echinopines has been stereo- selectively accessed through a gold(I)-catalyzed alkoxycyclization of cyclopropyl- tethered 1,6-enynes. The key bicyclo[4.2.1]nonane core of the enyne precursors was readily assembled by means of a Co-catalyzed [6 + 2] cycloaddition. Furthermore, the attempted alkoxycyclization of 1,5-enyne substrates revealed an uncovered cyclopropyl rearrangement that gives rise to [3,6,5,7] tetracyclic structures. |
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