Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study

Background: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: In this case–control study, we included a total of 146 patients with DR and...

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Autores: Alcubierre Calvo, Núria, Navarrete Muñoz, Eva María, Rubinat, Esther, Falguera, Mireia, Valls Marsal, Joan, Traveset Maeso, Alicia, Vilanova Fillat, María Belén, Marsal Mora, Josep Ramon, Hernández García, Marta, Granado Casas, Minerva, Martínez González, María Dolores, Jurjo Campo, Carmen, Franch-Nadal, Josep, Vioque, Jesus, Mauricio Puente, Dídac
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/57248
Acceso en línea:https://doi.org/10.1186/s12986-016-0099-5
http://hdl.handle.net/10459.1/57248
Access Level:acceso abierto
Palabra clave:Diabetic retinopathy
Oleic acid
Monounsaturated fatty acids
Fatty acids
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spelling Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control studyAlcubierre Calvo, NúriaNavarrete Muñoz, Eva MaríaRubinat, EstherFalguera, MireiaValls Marsal, JoanTraveset Maeso, AliciaVilanova Fillat, María BelénMarsal Mora, Josep RamonHernández García, MartaGranado Casas, MinervaMartínez González, María DoloresJurjo Campo, CarmenFranch-Nadal, JosepVioque, JesusMauricio Puente, DídacDiabetic retinopathyOleic acidMonounsaturated fatty acidsFatty acidsBackground: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR. Results: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0. 46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0. 23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer diabetes duration. Conclusion: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR.This study was supported by grant PS09/01035 from Instituto of Salud Carlos III. N.A holds a predoctoral fellowship from Instituto of Salud Carlos III FI11/ 0008. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative included in Plan Nacional de I + D + I and cofinanced by Instituto de Salud Carlos III Subdireccion General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER).BioMed Central2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1186/s12986-016-0099-5http://hdl.handle.net/10459.1/57248reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1186/s12986-016-0099-5Nutrition and Metabolism, 2016, vol. 13, núm. 40cc-by (c) Alcubierre et al., 2016info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/oai:repositori.udl.cat:10459.1/572482026-06-24T12:42:17Z
dc.title.none.fl_str_mv Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
spellingShingle Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
Alcubierre Calvo, Núria
Diabetic retinopathy
Oleic acid
Monounsaturated fatty acids
Fatty acids
title_short Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_full Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_fullStr Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_full_unstemmed Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_sort Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
dc.creator.none.fl_str_mv Alcubierre Calvo, Núria
Navarrete Muñoz, Eva María
Rubinat, Esther
Falguera, Mireia
Valls Marsal, Joan
Traveset Maeso, Alicia
Vilanova Fillat, María Belén
Marsal Mora, Josep Ramon
Hernández García, Marta
Granado Casas, Minerva
Martínez González, María Dolores
Jurjo Campo, Carmen
Franch-Nadal, Josep
Vioque, Jesus
Mauricio Puente, Dídac
author Alcubierre Calvo, Núria
author_facet Alcubierre Calvo, Núria
Navarrete Muñoz, Eva María
Rubinat, Esther
Falguera, Mireia
Valls Marsal, Joan
Traveset Maeso, Alicia
Vilanova Fillat, María Belén
Marsal Mora, Josep Ramon
Hernández García, Marta
Granado Casas, Minerva
Martínez González, María Dolores
Jurjo Campo, Carmen
Franch-Nadal, Josep
Vioque, Jesus
Mauricio Puente, Dídac
author_role author
author2 Navarrete Muñoz, Eva María
Rubinat, Esther
Falguera, Mireia
Valls Marsal, Joan
Traveset Maeso, Alicia
Vilanova Fillat, María Belén
Marsal Mora, Josep Ramon
Hernández García, Marta
Granado Casas, Minerva
Martínez González, María Dolores
Jurjo Campo, Carmen
Franch-Nadal, Josep
Vioque, Jesus
Mauricio Puente, Dídac
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diabetic retinopathy
Oleic acid
Monounsaturated fatty acids
Fatty acids
topic Diabetic retinopathy
Oleic acid
Monounsaturated fatty acids
Fatty acids
description Background: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. Methods: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR. Results: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0. 46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0. 23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer diabetes duration. Conclusion: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s12986-016-0099-5
http://hdl.handle.net/10459.1/57248
url https://doi.org/10.1186/s12986-016-0099-5
http://hdl.handle.net/10459.1/57248
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1186/s12986-016-0099-5
Nutrition and Metabolism, 2016, vol. 13, núm. 40
dc.rights.none.fl_str_mv cc-by (c) Alcubierre et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
rights_invalid_str_mv cc-by (c) Alcubierre et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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