Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice

Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabete...

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Autores: Sandoval, Viviana, Femenias, Antoni, Martínez-Garza, Úrsula, Sanz-Lamora, Hèctor, Castagnini, Juan Manuel|||0000-0002-3659-3640, Quifer-Rada, Paola|||0000-0003-2191-5501, Lamuela-Raventós, Rosa M.|||0000-0002-1287-4560, Marrero, Pedro F., Haro, Diego, Relat, Joana
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286420
Acceso en línea:https://ddd.uab.cat/record/286420
https://dx.doi.org/urn:doi:10.3390/antiox8090360
Access Level:acceso abierto
Palabra clave:Anthocyanins
Browning
Carbohydrate-responsive element binding protein b
Delphinidin
Fibroblast growth factor 21
High-fat diet
Maqui berry
White adipose tissue
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repository_id_str
spelling Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese miceSandoval, VivianaFemenias, AntoniMartínez-Garza, ÚrsulaSanz-Lamora, HèctorCastagnini, Juan Manuel|||0000-0002-3659-3640Quifer-Rada, Paola|||0000-0003-2191-5501Lamuela-Raventós, Rosa M.|||0000-0002-1287-4560Marrero, Pedro F.Haro, DiegoRelat, JoanaAnthocyaninsBrowningCarbohydrate-responsive element binding protein bDelphinidinFibroblast growth factor 21High-fat dietMaqui berryWhite adipose tissueMaqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A-stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286420https://dx.doi.org/urn:doi:10.3390/antiox8090360reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2017-82417-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-75329-RAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-683Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-196open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2864202026-06-06T12:50:31Z
dc.title.none.fl_str_mv Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
spellingShingle Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
Sandoval, Viviana
Anthocyanins
Browning
Carbohydrate-responsive element binding protein b
Delphinidin
Fibroblast growth factor 21
High-fat diet
Maqui berry
White adipose tissue
title_short Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_full Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_fullStr Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_full_unstemmed Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
title_sort Lyophilized maqui (Aristotelia chilensis) berry induces browning in the subcutaneous white adipose tissue and ameliorates the insulin resistance in high fat diet-induced obese mice
dc.creator.none.fl_str_mv Sandoval, Viviana
Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel|||0000-0002-3659-3640
Quifer-Rada, Paola|||0000-0003-2191-5501
Lamuela-Raventós, Rosa M.|||0000-0002-1287-4560
Marrero, Pedro F.
Haro, Diego
Relat, Joana
author Sandoval, Viviana
author_facet Sandoval, Viviana
Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel|||0000-0002-3659-3640
Quifer-Rada, Paola|||0000-0003-2191-5501
Lamuela-Raventós, Rosa M.|||0000-0002-1287-4560
Marrero, Pedro F.
Haro, Diego
Relat, Joana
author_role author
author2 Femenias, Antoni
Martínez-Garza, Úrsula
Sanz-Lamora, Hèctor
Castagnini, Juan Manuel|||0000-0002-3659-3640
Quifer-Rada, Paola|||0000-0003-2191-5501
Lamuela-Raventós, Rosa M.|||0000-0002-1287-4560
Marrero, Pedro F.
Haro, Diego
Relat, Joana
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anthocyanins
Browning
Carbohydrate-responsive element binding protein b
Delphinidin
Fibroblast growth factor 21
High-fat diet
Maqui berry
White adipose tissue
topic Anthocyanins
Browning
Carbohydrate-responsive element binding protein b
Delphinidin
Fibroblast growth factor 21
High-fat diet
Maqui berry
White adipose tissue
description Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A-stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/286420
https://dx.doi.org/urn:doi:10.3390/antiox8090360
url https://ddd.uab.cat/record/286420
https://dx.doi.org/urn:doi:10.3390/antiox8090360
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2017-82417-R
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-75329-R
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-683
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-196
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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