Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease

An abnormal plasma polyunsaturated fatty acid pattern (PUFA) (increased n3 and decreased n6 PUFA) has been reported in active inflammatory bowel disease (IBD). The possibility of a primary defect in the PUFA metabolism in IBD was hypothesised. The aim of this study was to assess plasma PUFA pattern...

ver descrição completa

Detalhes bibliográficos
Autores: Esteve i Comas, Maria, Núñez, M. C., Fernández Bañares, Fernando, Gil, Ángel, Cabré i Gelada, Eduard, González-Huix Lladó, Ferran, Bertrán, X., Gassull, Miquel Àngel, Abad Lacruz, Agueda
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:1993
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/18655
Acesso em linha:https://hdl.handle.net/2445/18655
Access Level:Acceso aberto
Palavra-chave:Malalties inflamatòries intestinals
Àcids grassos insaturats
Inflammatory bowel diseases
Unsaturated fatty acids
id ES_d6350112e4de7df10ca9db04660c49de
oai_identifier_str oai:recercat.cat:2445/18655
network_acronym_str ES
network_name_str España
repository_id_str
spelling Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel diseaseEsteve i Comas, MariaNúñez, M. C.Fernández Bañares, FernandoGil, ÁngelCabré i Gelada, EduardGonzález-Huix Lladó, FerranBertrán, X.Gassull, Miquel ÀngelAbad Lacruz, AguedaMalalties inflamatòries intestinalsÀcids grassos insaturatsInflammatory bowel diseasesUnsaturated fatty acidsAn abnormal plasma polyunsaturated fatty acid pattern (PUFA) (increased n3 and decreased n6 PUFA) has been reported in active inflammatory bowel disease (IBD). The possibility of a primary defect in the PUFA metabolism in IBD was hypothesised. The aim of this study was to assess plasma PUFA pattern in inactive inflammatory bowel disease and to ascertain whether patients who had had a colectomy and who were suffering from ulcerative colitis have a similar PUFA pattern than those patients with non-active ulcerative colitis and who had not had a colectomy. Plasma fatty acids were analysed by semi-capillary column gas-liquid chromatography in three groups of patients with inactive IBD (24 patients with inactive ulcerative colitis who had not had a colectomy, 15 patients with ulcerative colitis who had had a colectomy, and 27 patients with Crohn's disease). Plasma concentration and percentage of C22:6n3 and unsaturation index were significantly higher in patients with inactive ulcerative colitis without a colectomy and the Crohn's disease group (p < 0.0001) than in controls. Plasma concentration and percentage of C22:6n3 and the unsaturation index remained significantly higher, in both the operated and non-operated ulcerative colitis patients when compared with controls (p < 0.0001). These results suggest that in inactive IBD, an increased PUFA biosynthesis might be the cause of the high values of n3 compounds. These findings although seen in active disease, are more noticeable in remission because of the lack of artefactual factors (malnutrition, steroids, inflammation). In addition, persistence of high values in both groups of ulcerative colitis patients--that is, those who had had a colectomy and those who had not suggests the existence of a primary abnormality in the PUFA metabolism in IBD.BMJ Group201120111993info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/18655Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.34.10.1370Gut, 1993, vol. 34, núm. 10, p. 1370-1373http://dx.doi.org/10.1136/gut.34.10.1370(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1993info:eu-repo/semantics/openAccessoai:recercat.cat:2445/186552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
title Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
spellingShingle Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
Esteve i Comas, Maria
Malalties inflamatòries intestinals
Àcids grassos insaturats
Inflammatory bowel diseases
Unsaturated fatty acids
title_short Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
title_full Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
title_fullStr Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
title_full_unstemmed Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
title_sort Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease
dc.creator.none.fl_str_mv Esteve i Comas, Maria
Núñez, M. C.
Fernández Bañares, Fernando
Gil, Ángel
Cabré i Gelada, Eduard
González-Huix Lladó, Ferran
Bertrán, X.
Gassull, Miquel Àngel
Abad Lacruz, Agueda
author Esteve i Comas, Maria
author_facet Esteve i Comas, Maria
Núñez, M. C.
Fernández Bañares, Fernando
Gil, Ángel
Cabré i Gelada, Eduard
González-Huix Lladó, Ferran
Bertrán, X.
Gassull, Miquel Àngel
Abad Lacruz, Agueda
author_role author
author2 Núñez, M. C.
Fernández Bañares, Fernando
Gil, Ángel
Cabré i Gelada, Eduard
González-Huix Lladó, Ferran
Bertrán, X.
Gassull, Miquel Àngel
Abad Lacruz, Agueda
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties inflamatòries intestinals
Àcids grassos insaturats
Inflammatory bowel diseases
Unsaturated fatty acids
topic Malalties inflamatòries intestinals
Àcids grassos insaturats
Inflammatory bowel diseases
Unsaturated fatty acids
description An abnormal plasma polyunsaturated fatty acid pattern (PUFA) (increased n3 and decreased n6 PUFA) has been reported in active inflammatory bowel disease (IBD). The possibility of a primary defect in the PUFA metabolism in IBD was hypothesised. The aim of this study was to assess plasma PUFA pattern in inactive inflammatory bowel disease and to ascertain whether patients who had had a colectomy and who were suffering from ulcerative colitis have a similar PUFA pattern than those patients with non-active ulcerative colitis and who had not had a colectomy. Plasma fatty acids were analysed by semi-capillary column gas-liquid chromatography in three groups of patients with inactive IBD (24 patients with inactive ulcerative colitis who had not had a colectomy, 15 patients with ulcerative colitis who had had a colectomy, and 27 patients with Crohn's disease). Plasma concentration and percentage of C22:6n3 and unsaturation index were significantly higher in patients with inactive ulcerative colitis without a colectomy and the Crohn's disease group (p < 0.0001) than in controls. Plasma concentration and percentage of C22:6n3 and the unsaturation index remained significantly higher, in both the operated and non-operated ulcerative colitis patients when compared with controls (p < 0.0001). These results suggest that in inactive IBD, an increased PUFA biosynthesis might be the cause of the high values of n3 compounds. These findings although seen in active disease, are more noticeable in remission because of the lack of artefactual factors (malnutrition, steroids, inflammation). In addition, persistence of high values in both groups of ulcerative colitis patients--that is, those who had had a colectomy and those who had not suggests the existence of a primary abnormality in the PUFA metabolism in IBD.
publishDate 1993
dc.date.none.fl_str_mv 1993
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/18655
url https://hdl.handle.net/2445/18655
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.34.10.1370
Gut, 1993, vol. 34, núm. 10, p. 1370-1373
http://dx.doi.org/10.1136/gut.34.10.1370
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1993
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1993
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420817017733120
score 15,812429

Registros relacionados