Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort

BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA...

Descripción completa

Detalles Bibliográficos
Autores: Aglago, Elom K., Huybrechts, Inge, Murphy, Neil, Casagrande, Corinne, Nicolas, Geneviève, Pischon, Tobias, Fedirko, Veronika, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Katzke, Verena, Kühn, Tilman, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Lasheras, Cristina, Agudo, Antonio, Sánchez, María José, Amiano, Pilar, Huerta Castaño, José María, Ardanaz, Eva, Pérez Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno de Mesquita, H. Bas, May, Anne M., Derksen, Jeroen W. G., Hellstrand, Sophie, Ohlsson, Bodil, Wennberg, Maria, van Guelpen, Bethany, Skeie, Guri, Brustad, Magritt, Weiderpass, Elisabete, Cross, Amanda J., Ward, Heather, Riboli, Elio, Norat, Teresa, Chajès, Véronique, Gunter, Marc J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173253
Acceso en línea:https://hdl.handle.net/2445/173253
Access Level:acceso abierto
Palabra clave:Càncer colorectal
Àcids grassos insaturats
Colorectal cancer
Unsaturated fatty acids
Descripción
Sumario:BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; P-trend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; P-trend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; P-trend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; P-trend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; P-trend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (P-heterogeneity = .026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.

Similares en LA Referencia