Strontium and gallium doping enhances in vivo bone regeneration in biomimetic hydroxyapatite 3D-printed scaffolds.
Doping of calcium phosphates (CaPs) with bioinorganic ions is a widely used strategy to enhance their biological performance in bone regeneration. However, conventional methods for ionic incorporation in CaP scaffolds often require high-temperature treatments or involve multiple complex steps. Here,...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:dnet:r-fsjd______::2354a90ab89cc4373bbc0c5868134b1e |
| Acceso en línea: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=30354 |
| Access Level: | acceso abierto |
| Palabra clave: | 3D printing Biomimetic hydroxyapatite Bone regeneration Calcium phosphates Ion doping Osteoinduction Scaffold |
| Sumario: | Doping of calcium phosphates (CaPs) with bioinorganic ions is a widely used strategy to enhance their biological performance in bone regeneration. However, conventional methods for ionic incorporation in CaP scaffolds often require high-temperature treatments or involve multiple complex steps. Here, we present two simple strategies to dope 3D-printed CaP scaffolds via incorporation of ions into the apatitic phase during the hydrolysis of a-tricalcium phosphate (a-TCP) to calcium deficient hydroxyapatite (CDHA). In the first strategy, ions were incorporated directly into the printing ink, whereas in the second, undoped robocasted scaffolds were immersed in ionic solutions, allowing ion incorporation into precipitated CDHA during phase transformation. We investigated several ions, including strontium (Sr(2+)), magnesium (Mg(2+)), silicon (SiO(4) (4-)) and gallium (Ga(3+)). Sr(2+) and Ga(3+) were successfully incorporated into the scaffolds, either by direct ink doping (Sr(2+)) or by soaking in ionic solutions (Sr(2+) and Ga(3+)). Direct incorporation of Sr(2+) in the ink resulted in a higher ion loading and release, enhancing bone formation and bone quality, as evidenced by increased mineral-to-matrix ratio and Young's modulus, as well as osteoinductive properties relative to non-doped scaffolds. Furthermore, we demonstrated for the first time the osteoinductive capacity of Ga(3+) in an ectopic in vivo model. |
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