Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles

Nanotechnology changed the concept of treatment for a variety of diseases, producing a huge impact regarding drug and gene delivery. Among the different targeted diseases, osteoporosis has devastating clinical and economic consequences. Since current osteoporosis treatments present several side effe...

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Autores: Mora Raimundo, Patricia, Lozano Borregón, Daniel, Benito De Las Heras, Manuel R., Mulero, Francisca, Manzano García, Miguel, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8151
Acceso en línea:https://hdl.handle.net/20.500.14352/8151
Access Level:acceso abierto
Palabra clave:Osteoporosis
siRNAs
Combination therapy
Osteostatin
Mesoporous silica nanoparticles
Materiales
3312 Tecnología de Materiales
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spelling Osteoporosis Remission and New Bone Formation with Mesoporous Silica NanoparticlesMora Raimundo, PatriciaLozano Borregón, DanielBenito De Las Heras, Manuel R.Mulero, FranciscaManzano García, MiguelVallet Regí, María Dulce NombreOsteoporosissiRNAsCombination therapyOsteostatinMesoporous silica nanoparticlesMateriales3312 Tecnología de MaterialesNanotechnology changed the concept of treatment for a variety of diseases, producing a huge impact regarding drug and gene delivery. Among the different targeted diseases, osteoporosis has devastating clinical and economic consequences. Since current osteoporosis treatments present several side effects, new treatment approaches are needed. Recently, the application of small interfering RNA (siRNA) has become a promising alternative. Wnt/β-catenin signaling pathway controls bone development and formation. This pathway is negatively regulated by sclerostin, which knock-down through siRNA application would potentially promote bone formation. However, the major bottleneck for siRNA-based treatments is the necessity of a delivery vector, bringing nanotechnology as a potential solution. Among the available nanocarriers, mesoporous silica nanoparticles (MSNs) have attracted great attention for intracellular delivery of siRNAs. The mesoporous structure of MSNs permits the delivery of siRNAs together with another biomolecule, achieving a combination therapy. Here, we evaluate the effectiveness of a new potential osteoporosis treatment based on MSNs. Our proposed system was effective in delivering SOST siRNA and osteostatin through systemic injection to bone tissue. The nanoparticle administration produced an increase expression of osteogenic related genes improving the bone microarchitecture. The treated osteoporotic mice recovered values of a healthy situation approaching to osteoporosis remission.Wiley-VCH GmbHUniversidad Complutense de Madrid20212021-06-0620212021-06-06journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8151reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/81512026-06-02T12:44:21Z
dc.title.none.fl_str_mv Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
title Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
spellingShingle Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
Mora Raimundo, Patricia
Osteoporosis
siRNAs
Combination therapy
Osteostatin
Mesoporous silica nanoparticles
Materiales
3312 Tecnología de Materiales
title_short Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
title_full Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
title_fullStr Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
title_full_unstemmed Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
title_sort Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles
dc.creator.none.fl_str_mv Mora Raimundo, Patricia
Lozano Borregón, Daniel
Benito De Las Heras, Manuel R.
Mulero, Francisca
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
author Mora Raimundo, Patricia
author_facet Mora Raimundo, Patricia
Lozano Borregón, Daniel
Benito De Las Heras, Manuel R.
Mulero, Francisca
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
author_role author
author2 Lozano Borregón, Daniel
Benito De Las Heras, Manuel R.
Mulero, Francisca
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Osteoporosis
siRNAs
Combination therapy
Osteostatin
Mesoporous silica nanoparticles
Materiales
3312 Tecnología de Materiales
topic Osteoporosis
siRNAs
Combination therapy
Osteostatin
Mesoporous silica nanoparticles
Materiales
3312 Tecnología de Materiales
description Nanotechnology changed the concept of treatment for a variety of diseases, producing a huge impact regarding drug and gene delivery. Among the different targeted diseases, osteoporosis has devastating clinical and economic consequences. Since current osteoporosis treatments present several side effects, new treatment approaches are needed. Recently, the application of small interfering RNA (siRNA) has become a promising alternative. Wnt/β-catenin signaling pathway controls bone development and formation. This pathway is negatively regulated by sclerostin, which knock-down through siRNA application would potentially promote bone formation. However, the major bottleneck for siRNA-based treatments is the necessity of a delivery vector, bringing nanotechnology as a potential solution. Among the available nanocarriers, mesoporous silica nanoparticles (MSNs) have attracted great attention for intracellular delivery of siRNAs. The mesoporous structure of MSNs permits the delivery of siRNAs together with another biomolecule, achieving a combination therapy. Here, we evaluate the effectiveness of a new potential osteoporosis treatment based on MSNs. Our proposed system was effective in delivering SOST siRNA and osteostatin through systemic injection to bone tissue. The nanoparticle administration produced an increase expression of osteogenic related genes improving the bone microarchitecture. The treated osteoporotic mice recovered values of a healthy situation approaching to osteoporosis remission.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-06-06
2021
2021-06-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8151
url https://hdl.handle.net/20.500.14352/8151
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH GmbH
publisher.none.fl_str_mv Wiley-VCH GmbH
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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