In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients

Background and Aims Respiratory syncytial virus (RSV) mortality varies across different populations. This study aims to assess RSV mortality in hospitalized adults (>= 15 years) and identify key risk factors according to age.Methods This was a retrospective, single-center study conducted in Alica...

ver descrição completa

Detalhes bibliográficos
Autores: Valero-Sempere, F, Tortosa-González, M, Otero-Rodriguez, S, Ventero, M, Rodriguez-Diaz, JC, Casasnovas, P, Pinargote-Celorio, H, Sanchez-Martinez, R, Merino, E, Ramos-Rincon, JM
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:dnet:isabial_____::0707ae952425254e71d417766c85dc44
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones12541
Access Level:acceso abierto
Palavra-chave:aged
epidemics
hospitalizations
intensive care unit
length of stay
mortality
over 80 and older
respiratory syncytial virus
RSV
Spain
id ES_d51de89cd4d626bea2f3a64fcb5e5e1c
oai_identifier_str oai:dnet:isabial_____::0707ae952425254e71d417766c85dc44
network_acronym_str ES
network_name_str España
repository_id_str
spelling In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older PatientsValero-Sempere, FTortosa-González, MOtero-Rodriguez, SVentero, MRodriguez-Diaz, JCCasasnovas, PPinargote-Celorio, HSanchez-Martinez, RMerino, ERamos-Rincon, JMagedepidemicshospitalizationsintensive care unitlength of staymortalityover 80 and olderrespiratory syncytial virusRSVSpainBackground and Aims Respiratory syncytial virus (RSV) mortality varies across different populations. This study aims to assess RSV mortality in hospitalized adults (>= 15 years) and identify key risk factors according to age.Methods This was a retrospective, single-center study conducted in Alicante (Spain), including patients hospitalized for PCR-confirmed RSV infection between 2016 and 2023. Risk factors for death were assessed using multivariable logistic regression.Results Of 367 patients admitted for RSV, 24 died (6.5%). Mortality was higher in very old adults (>= 80 years, 8.9%) than in those aged under 80 years (4.8%). Significant risk factors were glomerular filtration rate (GFR) less than 38 mL/min/m2 (adjusted odds ratio [aOR] 3.15, 95% confidence interval [CI] 1.16-8.56), use of high-flow nasal cannula (aOR 3.67, 95% CI 1.15-11.74), and metastatic cancer (aOR 10.01, 95% CI 1.28-78.55). In the group <= 79 years (n = 210), risk factors were non-invasive mechanical ventilation (aOR 26.07 95% CI 2.01-338) and C-reactive protein levels over 11 mg/dL (aOR 12.48, 95% CI 1.14-136). In the patients >= 80 years (n = 157; 42.8%), low GFR was associated with higher mortality (aOR 4.53, 95% CI 1.36-15.04).Conclusion RSV deaths increase with age. In-hospital mortality was associated with non-invasive mechanical ventilation and C-reactive protein levels and in patients under 80, and low GFR in older patients.WILEY2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones12541Health Science ReportsISSN: 23988835reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:isabial_____::0707ae952425254e71d417766c85dc442026-06-12T10:20:37Z
dc.title.none.fl_str_mv In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
title In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
spellingShingle In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
Valero-Sempere, F
aged
epidemics
hospitalizations
intensive care unit
length of stay
mortality
over 80 and older
respiratory syncytial virus
RSV
Spain
title_short In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
title_full In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
title_fullStr In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
title_full_unstemmed In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
title_sort In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
dc.creator.none.fl_str_mv Valero-Sempere, F
Tortosa-González, M
Otero-Rodriguez, S
Ventero, M
Rodriguez-Diaz, JC
Casasnovas, P
Pinargote-Celorio, H
Sanchez-Martinez, R
Merino, E
Ramos-Rincon, JM
author Valero-Sempere, F
author_facet Valero-Sempere, F
Tortosa-González, M
Otero-Rodriguez, S
Ventero, M
Rodriguez-Diaz, JC
Casasnovas, P
Pinargote-Celorio, H
Sanchez-Martinez, R
Merino, E
Ramos-Rincon, JM
author_role author
author2 Tortosa-González, M
Otero-Rodriguez, S
Ventero, M
Rodriguez-Diaz, JC
Casasnovas, P
Pinargote-Celorio, H
Sanchez-Martinez, R
Merino, E
Ramos-Rincon, JM
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aged
epidemics
hospitalizations
intensive care unit
length of stay
mortality
over 80 and older
respiratory syncytial virus
RSV
Spain
topic aged
epidemics
hospitalizations
intensive care unit
length of stay
mortality
over 80 and older
respiratory syncytial virus
RSV
Spain
description Background and Aims Respiratory syncytial virus (RSV) mortality varies across different populations. This study aims to assess RSV mortality in hospitalized adults (>= 15 years) and identify key risk factors according to age.Methods This was a retrospective, single-center study conducted in Alicante (Spain), including patients hospitalized for PCR-confirmed RSV infection between 2016 and 2023. Risk factors for death were assessed using multivariable logistic regression.Results Of 367 patients admitted for RSV, 24 died (6.5%). Mortality was higher in very old adults (>= 80 years, 8.9%) than in those aged under 80 years (4.8%). Significant risk factors were glomerular filtration rate (GFR) less than 38 mL/min/m2 (adjusted odds ratio [aOR] 3.15, 95% confidence interval [CI] 1.16-8.56), use of high-flow nasal cannula (aOR 3.67, 95% CI 1.15-11.74), and metastatic cancer (aOR 10.01, 95% CI 1.28-78.55). In the group <= 79 years (n = 210), risk factors were non-invasive mechanical ventilation (aOR 26.07 95% CI 2.01-338) and C-reactive protein levels over 11 mg/dL (aOR 12.48, 95% CI 1.14-136). In the patients >= 80 years (n = 157; 42.8%), low GFR was associated with higher mortality (aOR 4.53, 95% CI 1.36-15.04).Conclusion RSV deaths increase with age. In-hospital mortality was associated with non-invasive mechanical ventilation and C-reactive protein levels and in patients under 80, and low GFR in older patients.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones12541
url https://isabial.portalinvestigacion.com/publicaciones12541
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Health Science Reports
ISSN: 23988835
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420628928364545
score 15,812429

Registos relacionados