In-Hospital Death and Risk Factors in Adults With Respiratory Syncytial Virus in Spain (2016-2023). A Cross-Sectional Study With Focus on Older Patients
Background and Aims Respiratory syncytial virus (RSV) mortality varies across different populations. This study aims to assess RSV mortality in hospitalized adults (>= 15 years) and identify key risk factors according to age.Methods This was a retrospective, single-center study conducted in Alica...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:dnet:isabial_____::0707ae952425254e71d417766c85dc44 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones12541 |
| Access Level: | acceso abierto |
| Palabra clave: | aged epidemics hospitalizations intensive care unit length of stay mortality over 80 and older respiratory syncytial virus RSV Spain |
| Sumario: | Background and Aims Respiratory syncytial virus (RSV) mortality varies across different populations. This study aims to assess RSV mortality in hospitalized adults (>= 15 years) and identify key risk factors according to age.Methods This was a retrospective, single-center study conducted in Alicante (Spain), including patients hospitalized for PCR-confirmed RSV infection between 2016 and 2023. Risk factors for death were assessed using multivariable logistic regression.Results Of 367 patients admitted for RSV, 24 died (6.5%). Mortality was higher in very old adults (>= 80 years, 8.9%) than in those aged under 80 years (4.8%). Significant risk factors were glomerular filtration rate (GFR) less than 38 mL/min/m2 (adjusted odds ratio [aOR] 3.15, 95% confidence interval [CI] 1.16-8.56), use of high-flow nasal cannula (aOR 3.67, 95% CI 1.15-11.74), and metastatic cancer (aOR 10.01, 95% CI 1.28-78.55). In the group <= 79 years (n = 210), risk factors were non-invasive mechanical ventilation (aOR 26.07 95% CI 2.01-338) and C-reactive protein levels over 11 mg/dL (aOR 12.48, 95% CI 1.14-136). In the patients >= 80 years (n = 157; 42.8%), low GFR was associated with higher mortality (aOR 4.53, 95% CI 1.36-15.04).Conclusion RSV deaths increase with age. In-hospital mortality was associated with non-invasive mechanical ventilation and C-reactive protein levels and in patients under 80, and low GFR in older patients. |
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