Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

Cell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the...

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Detalhes bibliográficos
Autores: de Mendoza, Alex, Suga, Hiroshi, Permanyer, Jon, Irimia Martínez, Manuel, Ruiz Trillo, Iñaki
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/58498
Acesso em linha:http://hdl.handle.net/10230/58498
http://dx.doi.org/10.7554/eLife.08904
Access Level:Acceso aberto
Palavra-chave:Cèl·lules
Éssers vius
Fongs
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spelling Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animalsde Mendoza, AlexSuga, HiroshiPermanyer, JonIrimia Martínez, ManuelRuiz Trillo, IñakiCèl·lulesÉssers viusFongsCell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the ichthyosporean Creolimax fragrantissima, a relative of animals that undergoes coenocytic development. We find that Creolimax utilizes dynamic regulation of alternative splicing, long inter-genic non-coding RNAs and co-regulated gene modules associated with animal multicellularity in a cell-type specific manner. Moreover, our study suggests that the different cell types of the three closest animal relatives (ichthyosporeans, filastereans and choanoflagellates) are the product of lineage-specific innovations. Additionally, a proteomic survey of the secretome reveals adaptations to a fungal-like lifestyle. In summary, the diversity of cell types among protistan relatives of animals and their complex genome regulation demonstrates that the last unicellular ancestor of animals was already capable of elaborate specification of cell types.European Research Council ERC-2007-StG-206883 to Alex de Mendoza, Hiroshi Suga, Iñaki Ruiz-Trillo. Ministerio de Economía y Competitividad BFU-2011-23434 to Alex de Mendoza. European Research Council ERC-2012-Co-616960 Alex de Mendoza. Japan Society for the Promotion of Science Research Activity to Hiroshi Suga. Center for Genomic Regulation Core funding to Jon Permanyer, Manuel Irimia Hiroshi Suga, Iñaki Ruiz-Trillo.eLife202320232015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/58498http://dx.doi.org/10.7554/eLife.08904reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)IngléseLife. 2015 Oct 14;4:e08904info:eu-repo/grantAgreement/EC/FP7/206883info:eu-repo/grantAgreement/ES/3PN/BFU-2011-23434info:eu-repo/grantAgreement/EC/FP7/616960© 2015, de Mendoza et al.This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/584982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
title Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
spellingShingle Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
de Mendoza, Alex
Cèl·lules
Éssers vius
Fongs
title_short Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
title_full Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
title_fullStr Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
title_full_unstemmed Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
title_sort Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
dc.creator.none.fl_str_mv de Mendoza, Alex
Suga, Hiroshi
Permanyer, Jon
Irimia Martínez, Manuel
Ruiz Trillo, Iñaki
author de Mendoza, Alex
author_facet de Mendoza, Alex
Suga, Hiroshi
Permanyer, Jon
Irimia Martínez, Manuel
Ruiz Trillo, Iñaki
author_role author
author2 Suga, Hiroshi
Permanyer, Jon
Irimia Martínez, Manuel
Ruiz Trillo, Iñaki
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules
Éssers vius
Fongs
topic Cèl·lules
Éssers vius
Fongs
description Cell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the ichthyosporean Creolimax fragrantissima, a relative of animals that undergoes coenocytic development. We find that Creolimax utilizes dynamic regulation of alternative splicing, long inter-genic non-coding RNAs and co-regulated gene modules associated with animal multicellularity in a cell-type specific manner. Moreover, our study suggests that the different cell types of the three closest animal relatives (ichthyosporeans, filastereans and choanoflagellates) are the product of lineage-specific innovations. Additionally, a proteomic survey of the secretome reveals adaptations to a fungal-like lifestyle. In summary, the diversity of cell types among protistan relatives of animals and their complex genome regulation demonstrates that the last unicellular ancestor of animals was already capable of elaborate specification of cell types.
publishDate 2015
dc.date.none.fl_str_mv 2015
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/58498
http://dx.doi.org/10.7554/eLife.08904
url http://hdl.handle.net/10230/58498
http://dx.doi.org/10.7554/eLife.08904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv eLife. 2015 Oct 14;4:e08904
info:eu-repo/grantAgreement/EC/FP7/206883
info:eu-repo/grantAgreement/ES/3PN/BFU-2011-23434
info:eu-repo/grantAgreement/EC/FP7/616960
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife
publisher.none.fl_str_mv eLife
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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