Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital

Objectives To study the prevalence and timing of neurological manifestations, including cognitive involvement, in patients hospitalized for Coronavirus disease 2019 (COVID-19). To analyze the pathogenic mechanisms and any association they have with disease severity. Methods Longitudinal cohort study...

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Autores: Barrachina-Esteve, O, Anguita, A, Reverter, A, Espinosa, J, Lafuente, C, Rubio-Roy, M, Crosas, M, Vila-Sala, C, Acero, C, Navarro, M, Canovas, D, Ribera, G, Jodar, M, Estela, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6266
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6266
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218820129&doi=10.1007%2Fs10072-025-08031-y&partnerID=40&md5=95330ae5d11ef55b60989f1dd435cc12
Access Level:acceso abierto
Palabra clave:Neurovirology
COVID-19
Clinical neurology
Cognitive disorders
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spelling Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospitalBarrachina-Esteve, OAnguita, AReverter, AEspinosa, JLafuente, CRubio-Roy, MCrosas, MVila-Sala, CAcero, CNavarro, MCanovas, DRibera, GJodar, MEstela, JNeurovirologyCOVID-19Clinical neurologyCognitive disordersObjectives To study the prevalence and timing of neurological manifestations, including cognitive involvement, in patients hospitalized for Coronavirus disease 2019 (COVID-19). To analyze the pathogenic mechanisms and any association they have with disease severity. Methods Longitudinal cohort study with prospective follow-up of patients who required hospitalization. Patients under 65 who had no pre-existing cognitive impairment and did not require an ICU stay were evaluated 3 and 12 months after discharge using a battery of neuropsychological tests. Results Of 205 patients hospitalized for COVID-19, 153 (74.6%) presented with neurological manifestations. The most frequent were myalgia (32.7%), headache (31.7%), dysgeusia (29.2%), and anosmia (24.9%). Patients with more severe illness at the time of hospitalization presented fewer neurological manifestations. Of the 62 patients who underwent neuropsychological examination 3 months after discharge, 22.6% had impaired attention, 19.4% impaired working memory, 16.1% impaired learning and retrieval, 9.7% impaired executive functions, and 8.2% impaired processing speed. Patients with anosmia also presented with more headache (OR 5.45; p < 0.001) and greater risk of working memory impairment (OR 5.87; p 0.03). At follow-up 12 months after hospital discharge, 14.3% of patients still showed impaired attention, 2.4% impaired working memory, 2.5% impaired executive functions, and 2.5% impaired processing speed. Discussion Neurological manifestations are common in patients hospitalized for COVID-19 regardless of severity. The high prevalence of anosmia and its association with headache and working memory impairment at 3 months, suggest potential direct or indirect damage to the prefrontal cortex via invasion of the olfactory bulb by COVID-19.SPRINGER-VERLAG ITALIA SRL2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6266https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218820129&doi=10.1007%2Fs10072-025-08031-y&partnerID=40&md5=95330ae5d11ef55b60989f1dd435cc12NEUROLOGICAL SCIENCESISSN: 15901874ISSNe: 15903478reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p62662026-06-21T15:30:37Z
dc.title.none.fl_str_mv Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
title Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
spellingShingle Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
Barrachina-Esteve, O
Neurovirology
COVID-19
Clinical neurology
Cognitive disorders
title_short Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
title_full Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
title_fullStr Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
title_full_unstemmed Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
title_sort Neurologic features in hospitalized patients with COVID-19: a prospective cohort in a catalan hospital
dc.creator.none.fl_str_mv Barrachina-Esteve, O
Anguita, A
Reverter, A
Espinosa, J
Lafuente, C
Rubio-Roy, M
Crosas, M
Vila-Sala, C
Acero, C
Navarro, M
Canovas, D
Ribera, G
Jodar, M
Estela, J
author Barrachina-Esteve, O
author_facet Barrachina-Esteve, O
Anguita, A
Reverter, A
Espinosa, J
Lafuente, C
Rubio-Roy, M
Crosas, M
Vila-Sala, C
Acero, C
Navarro, M
Canovas, D
Ribera, G
Jodar, M
Estela, J
author_role author
author2 Anguita, A
Reverter, A
Espinosa, J
Lafuente, C
Rubio-Roy, M
Crosas, M
Vila-Sala, C
Acero, C
Navarro, M
Canovas, D
Ribera, G
Jodar, M
Estela, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurovirology
COVID-19
Clinical neurology
Cognitive disorders
topic Neurovirology
COVID-19
Clinical neurology
Cognitive disorders
description Objectives To study the prevalence and timing of neurological manifestations, including cognitive involvement, in patients hospitalized for Coronavirus disease 2019 (COVID-19). To analyze the pathogenic mechanisms and any association they have with disease severity. Methods Longitudinal cohort study with prospective follow-up of patients who required hospitalization. Patients under 65 who had no pre-existing cognitive impairment and did not require an ICU stay were evaluated 3 and 12 months after discharge using a battery of neuropsychological tests. Results Of 205 patients hospitalized for COVID-19, 153 (74.6%) presented with neurological manifestations. The most frequent were myalgia (32.7%), headache (31.7%), dysgeusia (29.2%), and anosmia (24.9%). Patients with more severe illness at the time of hospitalization presented fewer neurological manifestations. Of the 62 patients who underwent neuropsychological examination 3 months after discharge, 22.6% had impaired attention, 19.4% impaired working memory, 16.1% impaired learning and retrieval, 9.7% impaired executive functions, and 8.2% impaired processing speed. Patients with anosmia also presented with more headache (OR 5.45; p < 0.001) and greater risk of working memory impairment (OR 5.87; p 0.03). At follow-up 12 months after hospital discharge, 14.3% of patients still showed impaired attention, 2.4% impaired working memory, 2.5% impaired executive functions, and 2.5% impaired processing speed. Discussion Neurological manifestations are common in patients hospitalized for COVID-19 regardless of severity. The high prevalence of anosmia and its association with headache and working memory impairment at 3 months, suggest potential direct or indirect damage to the prefrontal cortex via invasion of the olfactory bulb by COVID-19.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6266
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218820129&doi=10.1007%2Fs10072-025-08031-y&partnerID=40&md5=95330ae5d11ef55b60989f1dd435cc12
url https://i3pt.portalinvestigacion.com/publicaciones/6266
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218820129&doi=10.1007%2Fs10072-025-08031-y&partnerID=40&md5=95330ae5d11ef55b60989f1dd435cc12
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER-VERLAG ITALIA SRL
publisher.none.fl_str_mv SPRINGER-VERLAG ITALIA SRL
dc.source.none.fl_str_mv NEUROLOGICAL SCIENCES
ISSN: 15901874
ISSNe: 15903478
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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