Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain

Introduction: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child e...

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Autores: López, Y, Parra, E, Cepas, V, Sanfeliú, I, Juncosa, T, Andreu, A, Xercavins, M, Pérez, J, Sanz, S, Vergara, A, Bosch, J, Soto, SM
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5794
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/5794
Access Level:acceso abierto
Palavra-chave:Virulence
Serotypes
Antimicrobial resistance
Streptococcus agalactiae
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spelling Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, SpainLópez, YParra, ECepas, VSanfeliú, IJuncosa, TAndreu, AXercavins, MPérez, JSanz, SVergara, ABosch, JSoto, SMVirulenceSerotypesAntimicrobial resistanceStreptococcus agalactiaeIntroduction: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed. The aim of this study was to characterize and compare serotypes, virulence factors and antimicrobial resistance of GBS isolates collected from pregnant women and newborns in several hospitals in Catalonia. Methods: 242 GBS strains were analyzed including 95 colonizers and 68 pathogenic strains isolated from pregnant women, and 79 strains isolated from neonates with sepsis in order to determine serotype, virulence and antimicrobial resistance. Results: Serotype distribution was different among the three groups, with serotypes la and II being significantly more frequent among colonizing strains (p=0.001 and 0.012, respectively). Virulence factors bca and scpB were significantly more frequent among neonatal strains than pathogenic or colonizing strains (p = 0.0001 and 0.002, respectively). Pathogenic strains were significantly more resistant to erythromycin, clindamycin and azithromycin than their non-pathogenic counterparts. Conclusions: Taking into account that neonatal sepsis represents a significant problem on a global scale, epidemiological surveillance, antimicrobial resistance and GBS virulence at the local level could provide important knowledge about these microorganisms as well as help to improve treatment and prevent invasive infection caused by this microorganism. (C) 2017 Elsevier Espafia, S.L.U. and Sociedad Espafiola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.EDICIONES DOYMA S A2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5794ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICAISSN: 0213005XISSNe: 15781852reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Españolinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p57942026-06-21T15:30:37Z
dc.title.none.fl_str_mv Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
title Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
spellingShingle Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
López, Y
Virulence
Serotypes
Antimicrobial resistance
Streptococcus agalactiae
title_short Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
title_full Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
title_fullStr Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
title_full_unstemmed Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
title_sort Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in <i>Streptococcus agalactiae</i> isolates in pregnant women and neonates in Catalonia, Spain
dc.creator.none.fl_str_mv López, Y
Parra, E
Cepas, V
Sanfeliú, I
Juncosa, T
Andreu, A
Xercavins, M
Pérez, J
Sanz, S
Vergara, A
Bosch, J
Soto, SM
author López, Y
author_facet López, Y
Parra, E
Cepas, V
Sanfeliú, I
Juncosa, T
Andreu, A
Xercavins, M
Pérez, J
Sanz, S
Vergara, A
Bosch, J
Soto, SM
author_role author
author2 Parra, E
Cepas, V
Sanfeliú, I
Juncosa, T
Andreu, A
Xercavins, M
Pérez, J
Sanz, S
Vergara, A
Bosch, J
Soto, SM
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virulence
Serotypes
Antimicrobial resistance
Streptococcus agalactiae
topic Virulence
Serotypes
Antimicrobial resistance
Streptococcus agalactiae
description Introduction: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed. The aim of this study was to characterize and compare serotypes, virulence factors and antimicrobial resistance of GBS isolates collected from pregnant women and newborns in several hospitals in Catalonia. Methods: 242 GBS strains were analyzed including 95 colonizers and 68 pathogenic strains isolated from pregnant women, and 79 strains isolated from neonates with sepsis in order to determine serotype, virulence and antimicrobial resistance. Results: Serotype distribution was different among the three groups, with serotypes la and II being significantly more frequent among colonizing strains (p=0.001 and 0.012, respectively). Virulence factors bca and scpB were significantly more frequent among neonatal strains than pathogenic or colonizing strains (p = 0.0001 and 0.002, respectively). Pathogenic strains were significantly more resistant to erythromycin, clindamycin and azithromycin than their non-pathogenic counterparts. Conclusions: Taking into account that neonatal sepsis represents a significant problem on a global scale, epidemiological surveillance, antimicrobial resistance and GBS virulence at the local level could provide important knowledge about these microorganisms as well as help to improve treatment and prevent invasive infection caused by this microorganism. (C) 2017 Elsevier Espafia, S.L.U. and Sociedad Espafiola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5794
url https://i3pt.portalinvestigacion.com/publicaciones/5794
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EDICIONES DOYMA S A
publisher.none.fl_str_mv EDICIONES DOYMA S A
dc.source.none.fl_str_mv ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
ISSN: 0213005X
ISSNe: 15781852
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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