Fluoroquinolone-resistant Streptococcus agalactiae isolates from Argentina
Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005- 2007, WHONET - Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0,9%) of which proved to be resistant . Nine of them had come from 5 hosp...
| Autores: | , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | Argentina |
| Recursos: | Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
| Repositorio: | Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
| Idioma: | inglés |
| OAI Identifier: | oai:sgc.anlis.gob.ar:123456789/95 |
| Acesso em linha: | http://sgc.anlis.gob.ar/handle/123456789/95 http://www.scielo.org.ar/pdf/ram/v42n3/v42n3a11.pdf |
| Access Level: | acceso abierto |
| Palavra-chave: | Streptococcus agalactiae Fluoroquinolonas Argentina |
| Resumo: | Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005- 2007, WHONET - Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0,9%) of which proved to be resistant . Nine of them had come from 5 hospitals (in Buenos Aires City and 4 Argentinean provinces) and recovered from urine (n = 7) and vaginal screening cultures (n = 2). Three strains were also resistant to macrolides, lincosamides and B streptogramins due to the ermA gene. All nine fluoroquinolone-resistant isolates bore the same two mutations, Ser79Phe in ParC and Ser81Leu in GyrA proteins. Genetic relationships were analyzed by ApaI-PFGE and two clones were determined, A (n = 6) and B (n = 3). To our knowledge, these are the first fluoroquinolone-resistant S. agalactiae isolates detected in Latin America. |
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