Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions

The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a hig...

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Detalles Bibliográficos
Autores: Arcos Navarrete, Daniel, Gómez Cerezo, María Natividad, Saiz-Pardo Sanz, Melchor, Pablo Velasco, David De, Ortega Medina, Luis, Enciso, Silvia, Fernández Tomé, Blanca, Díaz Güemes, Idoia, Sánchez Margallo, Francisco Miguel, Casarrubios Palomar, Luis, Feito Castellano, María José, Portolés Pérez, María Teresa, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72100
Acceso en línea:https://hdl.handle.net/20.500.14352/72100
Access Level:acceso abierto
Palabra clave:Mesoporous bioactive nanoparticles
Osteoporosis
Bone regeneration
Ipriflavone
Hyaluronic acid
Sistema musculoesquelético
Bioquímica (Farmacia)
Química farmaceútica
2411.10 Fisiología del Músculo
2390 Química Farmacéutica
Descripción
Sumario:The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation.

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