Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
The overall objective of this PhD thesis has been the design of mesoporous nanoparticles for biomedical applications. In particular, this doctoral thesis has comprised the development of a nanocarrier for the potential treatment of bone diseases, more specifically in osteoporosis. The initial contex...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/11699 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/11699 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.71-007.234(043.2) Osteoporosis Sistema musculoesquelético 2411.10 Fisiología del Músculo |
| Sumario: | The overall objective of this PhD thesis has been the design of mesoporous nanoparticles for biomedical applications. In particular, this doctoral thesis has comprised the development of a nanocarrier for the potential treatment of bone diseases, more specifically in osteoporosis. The initial context of this doctoral thesis was the European project “VERDI” (“polyValent mEsopoRous naosystem for bone DIseases”). The proposal involved the use of mesoporous materials to treat three situations of clinical relevance in bone pathology: bone infection, bone cancer (primary tumors and bone metastases) and osteoporosis. Osteoporosis is considered the most prevalent disease involving bone degeneration. It is a silent disease and due to the aging population is considered one of the major public health problems facing postmenopausal women and aging individuals of both sexes. Although several effective antiosteoporotic treatments have been developed, their side effects limit their further application. Therefore, many efforts have been headed towards the development of other alternatives for osteoporosis treatment reducing their drawbacks for a better long-term use and adherence... |
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