Endoplasmic Reticulum Export of GPI-Anchored Proteins

Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo to the Golgi apparatus. The COPII machinery must adapt to the existing w...

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Detalles Bibliográficos
Autores: López Martín, Sergio, Rodríguez-Gallardo, Sofía, Sabido-Bozo, Susana, Muñíz, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/201394
Acceso en línea:http://hdl.handle.net/10261/201394
Access Level:acceso abierto
Palabra clave:Endoplasmic reticulum
COPII coat
GPI-anchored protein
p24 complex
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spelling Endoplasmic Reticulum Export of GPI-Anchored ProteinsLópez Martín, Sergio Rodríguez-Gallardo, SofíaSabido-Bozo, SusanaMuñíz, ManuelEndoplasmic reticulumCOPII coatGPI-anchored proteinp24 complexProtein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo to the Golgi apparatus. The COPII machinery must adapt to the existing wide variety of different types of cargo proteins and to different cellular needs for cargo secretion. The study of the ER export of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs), a special glycolipid-linked class of cell surface proteins, is contributing to address these key issues. Due to their special biophysical properties, GPI-APs use a specialized COPII machinery to be exported from the ER and their processing and maturation has been recently shown to actively regulate COPII function. In this review, we discuss the regulatory mechanisms by which GPI-APs are assembled and selectively exported from the ER.This research was funded by the Spanish Ministry of Economy and Competitiveness (MINECO), grant number BFU2017-89700-P to Manuel Muñiz. ‘V Own Research Plan’ of the University of Seville (VPPI-US) contract (cofounded by the European Social Fund) to Sergio Lopez. University of Seville fellowship to Sofía Rodriguez-Gallardo, Ministry of Education, Culture and Sport (MECD) fellowship to Susana Sabido-Bozo.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Universidad de SevillaEuropean CommissionMinisterio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/201394reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-89700-PBFU2017-89700-P/AEI/10.13039/501100011033https://doi.org/10.3390/ijms20143506Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2013942026-05-22T06:33:51Z
dc.title.none.fl_str_mv Endoplasmic Reticulum Export of GPI-Anchored Proteins
title Endoplasmic Reticulum Export of GPI-Anchored Proteins
spellingShingle Endoplasmic Reticulum Export of GPI-Anchored Proteins
López Martín, Sergio
Endoplasmic reticulum
COPII coat
GPI-anchored protein
p24 complex
title_short Endoplasmic Reticulum Export of GPI-Anchored Proteins
title_full Endoplasmic Reticulum Export of GPI-Anchored Proteins
title_fullStr Endoplasmic Reticulum Export of GPI-Anchored Proteins
title_full_unstemmed Endoplasmic Reticulum Export of GPI-Anchored Proteins
title_sort Endoplasmic Reticulum Export of GPI-Anchored Proteins
dc.creator.none.fl_str_mv López Martín, Sergio
Rodríguez-Gallardo, Sofía
Sabido-Bozo, Susana
Muñíz, Manuel
author López Martín, Sergio
author_facet López Martín, Sergio
Rodríguez-Gallardo, Sofía
Sabido-Bozo, Susana
Muñíz, Manuel
author_role author
author2 Rodríguez-Gallardo, Sofía
Sabido-Bozo, Susana
Muñíz, Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Universidad de Sevilla
European Commission
Ministerio de Educación, Cultura y Deporte (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Endoplasmic reticulum
COPII coat
GPI-anchored protein
p24 complex
topic Endoplasmic reticulum
COPII coat
GPI-anchored protein
p24 complex
description Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo to the Golgi apparatus. The COPII machinery must adapt to the existing wide variety of different types of cargo proteins and to different cellular needs for cargo secretion. The study of the ER export of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs), a special glycolipid-linked class of cell surface proteins, is contributing to address these key issues. Due to their special biophysical properties, GPI-APs use a specialized COPII machinery to be exported from the ER and their processing and maturation has been recently shown to actively regulate COPII function. In this review, we discuss the regulatory mechanisms by which GPI-APs are assembled and selectively exported from the ER.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/201394
url http://hdl.handle.net/10261/201394
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-89700-P
BFU2017-89700-P/AEI/10.13039/501100011033
https://doi.org/10.3390/ijms20143506
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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