Effect of polyphenolic dendrimers on biological and artificial lipid membranes

The use of dendrimers as nanovectors for nucleic acids or drugs requires the understanding of their interaction with biological membranes. This study investigates the impact of 1st generation polyphenolic carbosilane dendrimers on biological and model lipid membranes using several biophysical method...

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Autores: Grodzicka, Marika, Michlewska, Sylwia, Buczkowski, Adam, Ortega Lopez, Paula|||0000-0003-0377-5429, Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935, Bryszewska, Maria, Ionov, Maksim
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/63926
Acceso en línea:http://hdl.handle.net/10017/63926
https://dx.doi.org/10.1016/j.chemphyslip.2024.105444
Access Level:acceso abierto
Palabra clave:Polyphenolic dendrimers
DMPC/DPPG liposomes
Erythrocyte membrane
Haemotoxicity
Differential scanning calorimetry
Química
Chemistry
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spelling Effect of polyphenolic dendrimers on biological and artificial lipid membranesGrodzicka, MarikaMichlewska, SylwiaBuczkowski, AdamOrtega Lopez, Paula|||0000-0003-0377-5429Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935Bryszewska, MariaIonov, MaksimPolyphenolic dendrimersDMPC/DPPG liposomesErythrocyte membraneHaemotoxicityDifferential scanning calorimetryQuímicaChemistryThe use of dendrimers as nanovectors for nucleic acids or drugs requires the understanding of their interaction with biological membranes. This study investigates the impact of 1st generation polyphenolic carbosilane dendrimers on biological and model lipid membranes using several biophysical methods. While the increase in the z-average size of DMPC/DPPG liposomes correlated with the number of caffeic acid residues included in the dendrimer structure, dendrimers that contained polyethylene glycol chains generated lower zeta potential when interacting with a liposomal membrane. The increase in the fluorescence anisotropy of DPH and TMA-DPH probes incorporated into erythrocyte membranes predicted the ability of dendrimers to affect membrane fluidity in the hydrophobic interior and hydrophilic/polar region of a lipid bilayer. The presence of caffeic acid and polyethylene glycol chains in the dendrimer structure affected the thermodynamical properties of the membrane lipid matrix.Agencia Estatal de InvestigaciónJunta de Comunidades de Castilla-La ManchaUniversidad de AlcaláElsevier20242024-11-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/63926https://dx.doi.org/10.1016/j.chemphyslip.2024.105444reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-112924RB-I00 DESARROLLO DE NANOSISTEMAS DENDRITICOS PARA EL TRATAMIENTO Y%2FO PREVENCION DEL CANCER Y ENFERMEDADES INFECCIOSASJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F23%2F180225%2F000109UAH Not available PIUAH21%2FCC-041UAH Not available EPU-INV%2F2021%2F002open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/639262026-06-18T11:13:07Z
dc.title.none.fl_str_mv Effect of polyphenolic dendrimers on biological and artificial lipid membranes
title Effect of polyphenolic dendrimers on biological and artificial lipid membranes
spellingShingle Effect of polyphenolic dendrimers on biological and artificial lipid membranes
Grodzicka, Marika
Polyphenolic dendrimers
DMPC/DPPG liposomes
Erythrocyte membrane
Haemotoxicity
Differential scanning calorimetry
Química
Chemistry
title_short Effect of polyphenolic dendrimers on biological and artificial lipid membranes
title_full Effect of polyphenolic dendrimers on biological and artificial lipid membranes
title_fullStr Effect of polyphenolic dendrimers on biological and artificial lipid membranes
title_full_unstemmed Effect of polyphenolic dendrimers on biological and artificial lipid membranes
title_sort Effect of polyphenolic dendrimers on biological and artificial lipid membranes
dc.creator.none.fl_str_mv Grodzicka, Marika
Michlewska, Sylwia
Buczkowski, Adam
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author Grodzicka, Marika
author_facet Grodzicka, Marika
Michlewska, Sylwia
Buczkowski, Adam
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author_role author
author2 Michlewska, Sylwia
Buczkowski, Adam
Ortega Lopez, Paula|||0000-0003-0377-5429
Mata de la Mata, Francisco Javier de la|||0000-0003-0418-3935
Bryszewska, Maria
Ionov, Maksim
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Polyphenolic dendrimers
DMPC/DPPG liposomes
Erythrocyte membrane
Haemotoxicity
Differential scanning calorimetry
Química
Chemistry
topic Polyphenolic dendrimers
DMPC/DPPG liposomes
Erythrocyte membrane
Haemotoxicity
Differential scanning calorimetry
Química
Chemistry
description The use of dendrimers as nanovectors for nucleic acids or drugs requires the understanding of their interaction with biological membranes. This study investigates the impact of 1st generation polyphenolic carbosilane dendrimers on biological and model lipid membranes using several biophysical methods. While the increase in the z-average size of DMPC/DPPG liposomes correlated with the number of caffeic acid residues included in the dendrimer structure, dendrimers that contained polyethylene glycol chains generated lower zeta potential when interacting with a liposomal membrane. The increase in the fluorescence anisotropy of DPH and TMA-DPH probes incorporated into erythrocyte membranes predicted the ability of dendrimers to affect membrane fluidity in the hydrophobic interior and hydrophilic/polar region of a lipid bilayer. The presence of caffeic acid and polyethylene glycol chains in the dendrimer structure affected the thermodynamical properties of the membrane lipid matrix.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/63926
https://dx.doi.org/10.1016/j.chemphyslip.2024.105444
url http://hdl.handle.net/10017/63926
https://dx.doi.org/10.1016/j.chemphyslip.2024.105444
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-112924RB-I00 DESARROLLO DE NANOSISTEMAS DENDRITICOS PARA EL TRATAMIENTO Y%2FO PREVENCION DEL CANCER Y ENFERMEDADES INFECCIOSAS
Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available SBPLY%2F23%2F180225%2F000109
UAH Not available PIUAH21%2FCC-041
UAH Not available EPU-INV%2F2021%2F002
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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