Genome-wide analysis of factors affecting transcription elongation and DNA repair

RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide e...

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Detalles Bibliográficos
Autores: Gaillard, Hélène, Tous, Cristina, Botet, Javier, González Aguilera, Cristina, Quintero, María José, Viladevall Masbernat, Laia, García Rubio, María L., Rodríguez Gil, Alfonso|||0000-0003-4430-077X, Marín Rodríguez, Antonio, Ariño Carmona, Joaquín|||0000-0002-6774-2987, Revuelta, José Luis, Chávez, Sebastián, Aguilera, Andrés
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:112594
Acceso en línea:https://ddd.uab.cat/record/112594
https://dx.doi.org/urn:doi:10.1371/journal.pgen.1000364
Access Level:acceso abierto
Palabra clave:Transcription factors
DNA damage
Damage mechanics
Yeast
Mutation
Ultraviolet radiation
DNA repair
Descripción
Sumario:RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair. To improve our knowledge of transcription elongation and its coupling to TC-NER, we used the yeast library of non-essential knock-out mutations to screen for genes conferring resistance to the transcription-elongation inhibitor mycophenolic acid and the DNA-damaging agent 4-nitroquinoline-N-oxide. Our data provide evidence that subunits of the SAGA and Ccr4-Not complexes, Mediator, Bre1, Bur2, and Fun12 affect transcription elongation to different extents. Given the dependency of TC-NER on RNA Polymerase II transcription and the fact that the few proteins known to be involved in TC-NER are related to transcription, we performed an in-depth TC-NER analysis of a selection of mutants. We found that mutants of the PAF and Ccr4-Not complexes are impaired in TC-NER. This study provides evidence that PAF and Ccr4-Not are required for efficient TC-NER in yeast, unraveling a novel function for these transcription complexes and opening new perspectives for the understanding of TC-NER and its functional interconnection with transcription elongation.