Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
It has long been known that the process of transcription is a source of genetic instability. RNA molecules have been implicated in both the generation of DNA damage and, in the recent years, in its repair. These seemingly conflicting roles of RNA motivated us to open this research topic covering tra...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/271158 |
| Acceso en línea: | http://hdl.handle.net/10261/271158 |
| Access Level: | acceso abierto |
| Palabra clave: | DNA damage repair Genome stability R-loop DNA-RNA hybrids Transcription DSB repair |
| Sumario: | It has long been known that the process of transcription is a source of genetic instability. RNA molecules have been implicated in both the generation of DNA damage and, in the recent years, in its repair. These seemingly conflicting roles of RNA motivated us to open this research topic covering transcription-associated genetic instability sources and the role of RNA in the repair of DNA damage. The genome is challenged by both endogenous and exogenous sources of DNA damage. Additionally, failures in DNA metabolic processes, such as replication impairments or chromosomal miss-segregation, can threaten the transmission of the genetic information to the offspring by causing genome and chromosome instability. In particular, DNA transcription increases the frequency of mutation and recombination; this latter being caused, although not exclusively, by increased number of DNA double-strand breaks (DSBs), which are among the most harmful DNA lesions (Gaillard and Aguilera, 2016). RNA transcripts are constantly generated to supply for protein synthesis, RNA interference pathways, and regulation of transcription, translation, splicing as well as DNA repair processes via non-coding RNAs. Even heterochromatic regions can generate RNA molecules at telomeres (Azzalin et al., 2007; Luke et al., 2008; Schoeftner and Blasco, 2008) and centromeres (Saffery et al., 2003), that participate in the regulation of the telomeric (Fukagawa et al., 2004) and centromeric structures, thus impacting chromosome segregation and chromosome instability. The diverse roles of human centromeric RNA in chromosome stability were compiled by Leclerc and Kitagawa in this Frontiers Topic. |
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