SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

Gonzalez-Cao, Maria; Puertolas, Teresa; Martinez-Vila, Clara; Carrera, Cristina; Maldonado Seral, Cayetana; Rodriguez-Jimenez, Pedro; Sequero, Silvia; Cerezuela-Fuentes, Pablo; Feltes Ochoa, Rosa; Muñoz, Eva; Antoñanzas Basa, Mónica; Martín-Liberal, Juan; Soria, Ainara; Rodriguez-Moreno, Juan Francisco; Marquez-Rodas, Ivan; Lopez Criado, Pilar; Manzano, José Luis; Lopez-Castro, Rafael; Ayala de Miguel, Pablo; Villalobos, Laura; Martin Algarra, Salvador; Gonzalez-Barrallo, Ines; Boada, Aram; García Castaño, Almudena; Puig, Susana; Crespo, Guillermo; Luna Fra, Pablo; Aguayo Zamora, Cristina; Feito Rodriguez, Marta; Valles, Lara; Drozdowskyj, Ana; Gardeazabal, Jesús; Fernandez-Morales, Luis Antonio; Rodrigo, Alberto; Cruz, Raquel; Yelamos, Oriol; Rubio, Belen; Mujica, Karmele; Provencio, Mariano; Berrocal, Alfonso

SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ("GRAVID"). The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatmen...

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Autores:	Gonzalez-Cao, Maria, Puertolas, Teresa, Martinez-Vila, Clara, Carrera, Cristina, Maldonado Seral, Cayetana, Rodriguez-Jimenez, Pedro, Sequero, Silvia, Cerezuela-Fuentes, Pablo, Feltes Ochoa, Rosa, Muñoz, Eva, Antoñanzas Basa, Mónica, Martín-Liberal, Juan, Soria, Ainara, Rodriguez-Moreno, Juan Francisco, Marquez-Rodas, Ivan, Lopez Criado, Pilar, Manzano, José Luis, Lopez-Castro, Rafael, Ayala de Miguel, Pablo, Villalobos, Laura, Martin Algarra, Salvador, Gonzalez-Barrallo, Ines, Boada, Aram, García Castaño, Almudena, Puig, Susana, Crespo, Guillermo, Luna Fra, Pablo, Aguayo Zamora, Cristina, Feito Rodriguez, Marta, Valles, Lara, Drozdowskyj, Ana, Gardeazabal, Jesús, Fernandez-Morales, Luis Antonio, Rodrigo, Alberto, Cruz, Raquel, Yelamos, Oriol, Rubio, Belen, Mujica, Karmele, Provencio, Mariano, Berrocal, Alfonso
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/18876
Acceso en línea:	https://hdl.handle.net/20.500.13003/18876
Access Level:	acceso abierto
Palabra clave:	Child Aged, 80 and over Aged Diabetes Mellitus Young Adult SARS-CoV-2 Adult Humans Adolescent Melanoma Middle Aged Male Female COVID-19 Registries Femenino Adolescente Masculino Humanos Persona de Mediana Edad Adulto Joven Anciano Anciano de 80 o más Años Niño Adulto Sistema de Registros

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network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registryGonzalez-Cao, MariaPuertolas, TeresaMartinez-Vila, ClaraCarrera, CristinaMaldonado Seral, CayetanaRodriguez-Jimenez, PedroSequero, SilviaCerezuela-Fuentes, PabloFeltes Ochoa, RosaMuñoz, EvaAntoñanzas Basa, MónicaMartín-Liberal, JuanSoria, AinaraRodriguez-Moreno, Juan FranciscoMarquez-Rodas, IvanLopez Criado, PilarManzano, José LuisLopez-Castro, RafaelAyala de Miguel, PabloVillalobos, LauraMartin Algarra, SalvadorGonzalez-Barrallo, InesBoada, AramGarcía Castaño, AlmudenaPuig, SusanaCrespo, GuillermoLuna Fra, PabloAguayo Zamora, CristinaFeito Rodriguez, MartaValles, LaraDrozdowskyj, AnaGardeazabal, JesúsFernandez-Morales, Luis AntonioRodrigo, AlbertoCruz, RaquelYelamos, OriolRubio, BelenMujica, KarmeleProvencio, MarianoBerrocal, AlfonsoChildAged, 80 and overAgedDiabetes MellitusYoung AdultSARS-CoV-2AdultHumansAdolescentMelanomaMiddle AgedMaleFemaleCOVID-19RegistriesAged, 80 and overFemeninoCOVID-19AdolescenteMasculinoMelanomaDiabetes MellitusHumanosPersona de Mediana EdadSARS-CoV-2Adulto JovenAncianoAnciano de 80 o más AñosNiñoAdultoSistema de RegistrosThe Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ("GRAVID"). The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021. One hundred-fifty cases were registered. Median age was 68 years (range 6-95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February-May 2020, August-November 2020, and December 2020-April 2021. The first wave had the highest number of registered cases and COVID-19 mortality. Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection. NCT04344002.Springer20232023-03-0120232023-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/18876reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/188762026-06-22T12:44:07Z
dc.title.none.fl_str_mv	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
title	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
spellingShingle	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry Gonzalez-Cao, Maria Child Aged, 80 and over Aged Diabetes Mellitus Young Adult SARS-CoV-2 Adult Humans Adolescent Melanoma Middle Aged Male Female COVID-19 Registries Aged, 80 and over Femenino COVID-19 Adolescente Masculino Melanoma Diabetes Mellitus Humanos Persona de Mediana Edad SARS-CoV-2 Adulto Joven Anciano Anciano de 80 o más Años Niño Adulto Sistema de Registros
title_short	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
title_full	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
title_fullStr	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
title_full_unstemmed	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
title_sort	SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry
dc.creator.none.fl_str_mv	Gonzalez-Cao, Maria Puertolas, Teresa Martinez-Vila, Clara Carrera, Cristina Maldonado Seral, Cayetana Rodriguez-Jimenez, Pedro Sequero, Silvia Cerezuela-Fuentes, Pablo Feltes Ochoa, Rosa Muñoz, Eva Antoñanzas Basa, Mónica Martín-Liberal, Juan Soria, Ainara Rodriguez-Moreno, Juan Francisco Marquez-Rodas, Ivan Lopez Criado, Pilar Manzano, José Luis Lopez-Castro, Rafael Ayala de Miguel, Pablo Villalobos, Laura Martin Algarra, Salvador Gonzalez-Barrallo, Ines Boada, Aram García Castaño, Almudena Puig, Susana Crespo, Guillermo Luna Fra, Pablo Aguayo Zamora, Cristina Feito Rodriguez, Marta Valles, Lara Drozdowskyj, Ana Gardeazabal, Jesús Fernandez-Morales, Luis Antonio Rodrigo, Alberto Cruz, Raquel Yelamos, Oriol Rubio, Belen Mujica, Karmele Provencio, Mariano Berrocal, Alfonso
author	Gonzalez-Cao, Maria
author_facet	Gonzalez-Cao, Maria Puertolas, Teresa Martinez-Vila, Clara Carrera, Cristina Maldonado Seral, Cayetana Rodriguez-Jimenez, Pedro Sequero, Silvia Cerezuela-Fuentes, Pablo Feltes Ochoa, Rosa Muñoz, Eva Antoñanzas Basa, Mónica Martín-Liberal, Juan Soria, Ainara Rodriguez-Moreno, Juan Francisco Marquez-Rodas, Ivan Lopez Criado, Pilar Manzano, José Luis Lopez-Castro, Rafael Ayala de Miguel, Pablo Villalobos, Laura Martin Algarra, Salvador Gonzalez-Barrallo, Ines Boada, Aram García Castaño, Almudena Puig, Susana Crespo, Guillermo Luna Fra, Pablo Aguayo Zamora, Cristina Feito Rodriguez, Marta Valles, Lara Drozdowskyj, Ana Gardeazabal, Jesús Fernandez-Morales, Luis Antonio Rodrigo, Alberto Cruz, Raquel Yelamos, Oriol Rubio, Belen Mujica, Karmele Provencio, Mariano Berrocal, Alfonso
author_role	author
author2	Puertolas, Teresa Martinez-Vila, Clara Carrera, Cristina Maldonado Seral, Cayetana Rodriguez-Jimenez, Pedro Sequero, Silvia Cerezuela-Fuentes, Pablo Feltes Ochoa, Rosa Muñoz, Eva Antoñanzas Basa, Mónica Martín-Liberal, Juan Soria, Ainara Rodriguez-Moreno, Juan Francisco Marquez-Rodas, Ivan Lopez Criado, Pilar Manzano, José Luis Lopez-Castro, Rafael Ayala de Miguel, Pablo Villalobos, Laura Martin Algarra, Salvador Gonzalez-Barrallo, Ines Boada, Aram García Castaño, Almudena Puig, Susana Crespo, Guillermo Luna Fra, Pablo Aguayo Zamora, Cristina Feito Rodriguez, Marta Valles, Lara Drozdowskyj, Ana Gardeazabal, Jesús Fernandez-Morales, Luis Antonio Rodrigo, Alberto Cruz, Raquel Yelamos, Oriol Rubio, Belen Mujica, Karmele Provencio, Mariano Berrocal, Alfonso
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Child Aged, 80 and over Aged Diabetes Mellitus Young Adult SARS-CoV-2 Adult Humans Adolescent Melanoma Middle Aged Male Female COVID-19 Registries Aged, 80 and over Femenino COVID-19 Adolescente Masculino Melanoma Diabetes Mellitus Humanos Persona de Mediana Edad SARS-CoV-2 Adulto Joven Anciano Anciano de 80 o más Años Niño Adulto Sistema de Registros
topic	Child Aged, 80 and over Aged Diabetes Mellitus Young Adult SARS-CoV-2 Adult Humans Adolescent Melanoma Middle Aged Male Female COVID-19 Registries Aged, 80 and over Femenino COVID-19 Adolescente Masculino Melanoma Diabetes Mellitus Humanos Persona de Mediana Edad SARS-CoV-2 Adulto Joven Anciano Anciano de 80 o más Años Niño Adulto Sistema de Registros
description	The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ("GRAVID"). The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021. One hundred-fifty cases were registered. Median age was 68 years (range 6-95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February-May 2020, August-November 2020, and December 2020-April 2021. The first wave had the highest number of registered cases and COVID-19 mortality. Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection. NCT04344002.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-03-01 2023 2023-03-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/18876
url	https://hdl.handle.net/20.500.13003/18876
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer
publisher.none.fl_str_mv	Springer
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

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